Biochemical and physiological studies on the production of some pharmaceutical compounds / (Record no. 64191)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02869cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031902.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171223s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.07.04.M.Sc.2017.Is.B |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ismail Guda Said Ismail |
| 245 10 - TITLE STATEMENT | |
| Title | Biochemical and physiological studies on the production of some pharmaceutical compounds / |
| Statement of responsibility, etc. | Ismail Guda Said Ismail ; Supervised Emam Abdelmobdy Abdelrahim , Magdy Abdelaleem Mohamed Shallan , Kamal Yousef Ibraheim Eshahed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسات كيميائية حيوية وفسيولوجية على إنتاج بعض المركبات الدوائية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ismail Guda Said Ismail , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 150 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Agriculture- Department of Agriculture Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The main objective of the present study is to improve clavulanic acid (CA) production using UV-mutagenesis on Streptomyces sp. NRC 77. From the screened mutants, 120A3 mutant isolate was selected as a promising one .The biochemical, morphological, physiological properties of 120A3 mutant showed culture characteristics similar to Streptomyces sp. Phylogenetic analysis of the 16S rDNA gene sequence showed that this strain has a similarity of (99 %) to Streptomyces sp. T2-7, therefore it was suggested as Streptomyces sp. MU-NRC 77 and its nucleotide sequence was deposited in Gen Bank under the accession No. KT953342. Improvement of CA yield by 572.49 mg/l was obtained from fermentation medium and culture condition optimization in compared with 130.69 mg/l for wild strain. Further optimized by the addition of H2O2 and activated plant charcoal (1%) to the production medium increased CA yield strongly to reach 646.12 and 682.94 mg/l respectively by production incresement 5.2 fold more than that obtained before adding. Production of CA by the new selected Streptomyces mutated isolate using bioreactor 7L under optimized medium and conditions (agitation speed effect) afforded the highest CA yield 719.75 mg/l at 600 rpm by production incresement 5.5 fold in comparison with the wild strain, then extraction, purification of the CA from fermentation broth and chemical elucidation was carried out using different spectroscopic analysis |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Clavulanic acid |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Phylogenic analysis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | UV-mutagenesis |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Emam Abdelmobdy Abdelrahim , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kamal Yousef Ibraheim Eshahed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Magdy Abdelaleem Mohamed Shallan , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.07.04.M.Sc.2017.Is.B | 01010110073871000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.07.04.M.Sc.2017.Is.B | 01020110073871000 | 22.09.2023 | CD - Rom | 73871.CD |