Analysis of granzyme b-expressing b cells in siv-infected rhesus macaques / (Record no. 64201)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02931cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171224s2017 ua o f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.10.17.M.Sc.2017.Ah.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ahmad Hassan Kotb |
| 245 10 - TITLE STATEMENT | |
| Title | Analysis of granzyme b-expressing b cells in siv-infected rhesus macaques / |
| Statement of responsibility, etc. | Ahmad Hassan Kotb ; Supervised Mohamed Abdelhameed Shalaby , Ahmed Abdelghani Elsanousi , Momtaz Abdelhadi Afify Shaheen |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تحليل الخلايا ب الليمفاوية الفارزة لجرانزايم ب فى قردة المكاك الريسوسى المصابه بفيروس نقص المناعة المكتسبة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ahmad Hassan Kotb , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 100 P. : |
| Other physical details | photographs ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Virology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | HIV infection continues to be a major global health issue and is characterized by a profound dysregulation of various immune cells, including B cells. Recently, increased frequencies of regulatory, granzyme B-expressing B cells have been identified in HIV-infected patients compared to healthy subjects, but their function remains unclear. Due to limitations in studies with HIV-infected individuals, animal studies are needed. To date, the experimental infection of rhesus macaques (Macaca mulatta) with simian immunodefiency virus (SIV) is the best animal model for HIV/AIDS research. The aim of this work was to analyse frequencies, phenotype and the possible function of granzyme B-expressing B cells in healthy and SIV-infected rhesus macaques. Then B cells were purified using magnetic cell separation and different stimulation protocols were applied to induce granzyme B expression in vitro. Finally Co-culture experiments of these in vitro induced granzyme B-expressing B cells with T cells performed. Furthermore, we aimed at analyzing these cells in so-called long-term survivors (LTS), which lack disease progression in the absence of antiretroviral therapy, but can suddenly lose this status and progress to AIDS. By using multicolor flow cytometry the phenotype and frequencies of granzyme B-expressing B cells have been assessed and correlated with other immunologic parameters. Similar to HIV patients, significantly higher frequencies of these cells have been found in the blood of chronically SIV-infected rhesus monkeys compared with uninfected healthy ones |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Long term-survivors |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Rhesus macaques |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | SIV |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Abdelghani Elsanousi , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Abdelhameed Shalaby , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Momtaz Abdelhadi Afify Shaheen , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.10.17.M.Sc.2017.Ah.A | 01010110073924000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.10.17.M.Sc.2017.Ah.A | 01020110073924000 | 22.09.2023 | CD - Rom | 73924.CD |