Detection with Proton MR Spectroscopy of cerebral metabolic changes in children with type I diabetes mellitus / (Record no. 64234)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03622cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031903.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171225s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.31.M.Sc.2017.Mi.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mina Ramzy Emanuel Yacoub |
| 245 10 - TITLE STATEMENT | |
| Title | Detection with Proton MR Spectroscopy of cerebral metabolic changes in children with type I diabetes mellitus / |
| Statement of responsibility, etc. | Mina Ramzy Emanuel Yacoub ; Supervised Hassan Ali Elkiki , Abeer Atef Ashmawy , Rania Hamdy Hashem |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التحديد باستخدام الرنين الطيفي التغيرات الأيضية الدماغية لدى الأطفال الذين يعانون من داء السكري من النوع الأول |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mina Ramzy Emanuel Yacoub , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 76 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Radio-diagnosis |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Magnetic resonance spectroscopy (MRS) is an imaging diagnostic method that allows non-invasive measurement of metabolites in tissues. MRS may demonstrate metabolic changes in normal appearing MRI examinations. Long term impairment of cognitive function can occur in patients with type I diabetes mellitus (DM). Objective: In this study, we used MRS to investigate the impact of DM on brain neuro-chemical profile. Patients & Methods: MR spectroscopic analysis was performed on 12 children diagnosed with type I DM and 12 age-matched volunteer healthy subjects. The duration of the disease, number of diabetic keto-acidosis episodes (DKA), number of hypoglycemic events and the level of hemoglobin A1C (HbA1C) in the patients were noted. Voxels were placed in the right posterior parietal white matter, the occipital gray matter and the right basal ganglia. Single-voxel MRS with intermediate TE (144 ms) was performed in all 3 regions of interest plus short TE (34.5 ms) done only in the right posterior parietal white matter. N-acetylaspartate (NAA)/Creatinine (Cr) and Choline (Cho)/Cr ratios were recorded and compared between diabetic children and control subjects. The ratios collected from the diabetic group were correlated with the clinical data obtained. The presence of a significant lactate peak was also recorded. Results: Type 1 diabetic subjects had lower NAA/Cr ratio in the white matter than control subjects. Longer duration of DM and increased number of DKA episodes predicted lower NAA/Cr ratio. The study also revealed slightly higher Cho/Cr ratios in the gray matter and basal ganglia in diabetic patients. No other significant differences in the metabolite ratios between the diabetic and control groups. Significant lactate peaks were detected in some diabetic patients performing the exam post recovery from DKA. Conclusion: The decrease in NAA indicates reduced neuronal density or neuronal dysfunction as a consequence of long term poorly controlled type 1 DM. The explanation for the increase in Cho may be demyelination/gliosis or increased membrane turnover. The presence of lactate peaks suggest anaerobic metabolism during DKA |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Brain |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MR spectroscopy |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Type 1 diabetes mellitus |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abeer Atef Ashmawy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hassan Ali Elkiki , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rania Hamdy Hashem , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.31.M.Sc.2017.Mi.D | 01010110073880000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.31.M.Sc.2017.Mi.D | 01020110073880000 | 22.09.2023 | CD - Rom | 73880.CD |