MARC details
| 000 -LEADER |
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| fixed length control field |
02028cam a2200313 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
171225s2017 ua f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.05.M.Sc.2017.Ma.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mai Ibrahim Aboelmagd Ali |
| 245 10 - TITLE STATEMENT |
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| Title |
Synthesis and anticonvulsant evaluation of certain moieties derived from diazaspiroalkanediones / |
| Statement of responsibility, etc. |
Mai Ibrahim Aboelmagd Ali ; Supervised Mohamed Nabil Aboul-Enein , Kamilia Mahmoud Amin |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تشييد وتقييم الفاعلية المضادة للتشنجات لبعض الجزيئات المشتقة من ثنائي ازاسبيرو الكان داي اون |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Mai Ibrahim Aboelmagd Ali , |
| Date of publication, distribution, etc. |
2017 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
147 P. ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
This work deals with the synthesis of novel structures of: 1-[(2-hydroxyethyl)(aryl)amino]-N-substituted cycloalkanecarboxamides (IXa-l) and 2-[(1-substituted carbamoyl)cycloalkyl)(aryl)amino] ethyl acetates (Xa-l) derived from certain diazaspiroalkanediones. The newly synthesized compounds displayed an anticonvulsant activity using the subcutaneous pentylenetetrazole (scPTZ) and maximal electroshock seizure (MES) tests. The compounds were devoid of neurotoxicity in rotarod test. The most potent compounds in the scPTZ screen were Xh, Xd, Xf, IXj, Xl and Xi. Compound Xf was active as a new anticonvulsant agent in both scPTZ and MES screens. Also, a molecular modeling study was performed for the designed target compounds using Autodock 1.5.6 |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Anticonvulsant |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Diazaspiroalkanediones |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Molecular modeling |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Kamilia Mahmoud Amin , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed Nabil Aboul-Enein , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
