Study on protective effect of certain natural products against d-galactosamineinduced hepatotoxicity in rats / (Record no. 64269)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03122cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031904.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171225s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2016.Em.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Eman Mohamed Aly El-Hendy |
| 245 10 - TITLE STATEMENT | |
| Title | Study on protective effect of certain natural products against d-galactosamineinduced hepatotoxicity in rats / |
| Statement of responsibility, etc. | Eman Mohamed Aly Elhendy ; Supervised Ezzeddin Eldenshary , Amany I. Elbrairy , Rania M. Abdelsalam |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة عن التأثير الوقائي لبعض المواد الطبيعية ضد التسمم الكبدى الوبائى بإستخدام دى-جالكتوزامين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Eman Mohamed Aly El-Hendy , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 135 P. : |
| Other physical details | charts , facsimiles; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | D-galactosamine-induced hepatotoxicity in rats is an experimental model recognized to simulate viral hepatitis in humans from both morphological and functional points of view.Ü-lipoic acid and taurine are known as potential natural anti-oxidant and anti-inflammatory. Hence the present study aimed to investigate the effect of curcumin, taurine, Ü-lipoic acid alone or in combination on D-galactosamine-induced hepatotoxicity in rats. Male albino rats were divided into seven groups; both groups 1 and 2 received 1% tween 80 in normal saline, groups 3,4,5,6 and 7 received curcumin, taurine, Ü-lipoic acid, curcumin combined with taurine and cucumin combined with Ü-lipoic acid of same doses (50mg/kg, po) respectively for 15 days. On the 15th day, D-galactosamine (500mg/kg, ip) was administered to all groups except for normal control group that was given 0.5ml normal saline. 24 hours following D-galactosamine administration, blood samples were collected and animals were sacrificed and their livers were isolated. D-galactosamine resulted in a significant increase in activity of aminotransferases, alkaline phosphatase and total bilirubin. These findings were supported by histopathology. Also decreased SOD activity, increased lipid peroxidation in both serum and tissue homogenates and showed a significant increase in inflammatory mediators; TNF-Üand IL-10. Pretreatment with curcumin, taurine, Ü-lipoic acid, and alone or in combination mitigated most of these alterations. Curcumin, Ü-lipoic acid and their combination could be regarded as an effective strategy for protection against acute liver injury through their antioxidant and anti-inflammatory properties. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | D-galactosamine |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatotoxicity |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Viral hepatitis |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amany I. Elbrairy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ezzeddin Eldenshary , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rania M. Abdelsalam , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2016.Em.S | 01010110073899000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2016.Em.S | 01020110073899000 | 22.09.2023 | CD - Rom | 73899.CD |