The effect of irbesartan in 2,4,6-trinitrobenzene sulfonic acid induced ulcerative colitis in rats / (Record no. 64282)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03367cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031905.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171227s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2017.Am.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Amal Ahmed Ahmed Basaer |
| 245 14 - TITLE STATEMENT | |
| Title | The effect of irbesartan in 2,4,6-trinitrobenzene sulfonic acid induced ulcerative colitis in rats / |
| Statement of responsibility, etc. | Amal Ahmed Ahmed Basaer ; Supervised Dalaal Moustafa Abdallah , Hanan Salah Eldin Elabhar , Mai Ahmed Galal |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تأث{u٠٦أأ}رالإ{u٠٦أأ}رب{u٠٦أأ}سارتان في إلتھاب القولون التقرحي المحدث بمادة ٦:٤:٢ تري ن{u٠٦أأ}تروبنز{u٠٦أأ}ن سلفون{u٠٦أأ}ك أس{u٠٦أأ}د في الجراذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Amal Ahmed Ahmed Basaer , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 159 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Angiotensin (Ang) II plays a pivotal role in the pathogenesis of inflammatory bowel disease (IBD). Both ACEI and Ang II type 1 receptor blockers (ARBs) possess anticolitic efficacy; however, irbesartan (Irb) potential anti-ulcerative properties has not been reported previously. Colitis was induced in male Wistar rats by the rectal installation of 2,4,6-trinitrobenzene sulfonic acid (TNBS). Animals were divided into control, TNBS, sulfasalazine (Sulfz; 300 mg/kg), Irb (30 and 100 mg/kg), and combination (Sulfz/Irb30) groups. Irb at both dose levels attenuated the severity of colitis, as evidenced by decrease of ulcerative area, colon/spleen mass index, weight loss, and histopathological findings. It reduced the inflammatory response, via attenuation of nuclear factor (NF)-mB p65, tumor necrosis factor-{uF061}, interleukin-6, intracellular adhesion molecule-1, as well as myeloperoxidase activity. The drug was also able to restore junctional adhesion molecule (JAM)-A and trefoil factor (TFF)-3 to decrease epithelial barrier dysfunction. In association, the ARB was able to halt oxidative stress evidenced by the suppression of lipid peroxidation and capase-3, a marker of apoptosis. Besides, it increased nuclear factor nuclear factor (erythroidderived 2)-like-2 and hemeoxygenase-1. These effects were more prominent with the 100 mg/kg dose that was comparable to Sulfz. Meanwhile, the combination with Irb surpassed the anti-inflammatory, antioxidant and antiapoptotic effects and improved barrier strengthening mediated by Sulfz alone; however it did not modulate the reduction in the ulcer severity produced by Sulfz alone. In conclusion, Irb hampers IBD through the modulation of colonic inflammation, oxidative stress, and apoptosis, as well as enhancement of TFF-3 to preserve the tight junction JAM-A improving gut barrier function. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Apoptosis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Inflammation |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Oxidative stress |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dalaal Moustafa Abdallah , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Salah Eldin Elabhar , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mai Ahmed Galal , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2017.Am.E | 01010110073903000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2017.Am.E | 01020110073903000 | 22.09.2023 | CD - Rom | 73903.CD |