Relation between GSTP1 polymorphism and oxidative stress in patients with hepatocellular carcinoma in the national cancer institute, Egypt / (Record no. 64314)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02727cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031906.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171203s2017 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.19.03.Ph.D.2017.Sh.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Shaimaa Gamal Hassan Elofey |
| 245 10 - TITLE STATEMENT | |
| Title | Relation between GSTP1 polymorphism and oxidative stress in patients with hepatocellular carcinoma in the national cancer institute, Egypt / |
| Statement of responsibility, etc. | Shaimaa Gamal Hassan Elofey ; Supervised Iman Attia Abdelgawad , Osman Mohammed Mansour , Nevine Fawzy Shafik |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | و الاجهاد التاكسدى فى مرضى سرطان الخليه الكبديه فى مصر GSTP1 العلاقه بين تعدد اشكال جين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Shaimaa Gamal Hassan Elofey , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 204 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Hepatocellular carcinoma (HCC) is a major health problem in Egypt. It is third most common cause of cancer deaths worldwide. Both the immune response to hepatitis viral infection and oxidative stress are involved in the pathogenesis of HCC. Objective: To observe the relation between GSH as a marker of oxidative stress and polymorphism of GSTP1 gene which catalyzes conjugation of reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification. Methods: The patients were recruited from the medical oncology department, National cancer institute, Cairo university as well as the National liver institute Shebein Elkawm Elmonofeya over a period from November 2014 to August 2016. The methods we used were Ellman's colorimetric method for plasma GSH determination and GSTP1gene polymorphism determination samples of 99 adult patients with HCC. Results: The study revealed no significant relation between GSTP1gene phenotype and plasma level of GSH in HCC patients. Prevalence of mutant GSTP1 was higher among the HCC patients compared to the normal control group. There was no significant difference between the patient and control groups as regards the plasma GSH levels (p=0.152) besides its low sensitivity (38%) and specificity (53%) |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | GSTP1 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatocellular carcinoma |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Oxidative stress |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Iman Attia Abdelgawad , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nevine Fawzy Shafik , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Osman Mohammed Mansour , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.19.03.Ph.D.2017.Sh.R | 01010110073953000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.19.03.Ph.D.2017.Sh.R | 01020110073953000 | 22.09.2023 | CD - Rom | 73953.CD |