Possible protective effect of melatonin on cisplatin-induced testicular toxicity in adult albino rats : (Record no. 64645)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02765cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031917.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180122s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.16.Ph.D.2017.Kh.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Khaled Ragab Abdelhakim |
| 245 10 - TITLE STATEMENT | |
| Title | Possible protective effect of melatonin on cisplatin-induced testicular toxicity in adult albino rats : |
| Remainder of title | A histological and immunohistochemical study / |
| Statement of responsibility, etc. | Khaled Ragab Abdelhakim ; Supervised Soheir Assaad Filobbos , Noha Mohamed Afifi Amin , Mira Farouk Youssef |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التأثير الوقائي المحتمل للميلاتونين علي سمية الخصية المستحث بالسيسبلاتين في الجرذان البيضاء البالغة : |
| Remainder of title | دراسة هستولوجية و هستوكيميائية مناعية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Khaled Ragab Abdelhakim , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 175 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Histology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Chemotherapy may result in temporary or permanent gonadal toxicity in male patients. Loss of fertility potential can be devastating to patients, especially, during the child-bearing period. The present study was planned to investigate the possible protective effect of melatonin, in a rat model of cisplatin-induced testicular toxicity. Forty five adult male albino rats were divided into four groups; Group I Control (n=15) received 0.9% sodium chloride and/or distilled water as a vehicle. Group II (n=10) were injected intraperitoneally (I.P.) with a single dose 7 mg/kg of cisplatin & were sacrificed after 10 days. Group III (n=10) received melatonin daily orally at a dose of 8 mg/kg/day for 10 days. Group IV (n=10); oral melatonin administration started 5 days before the single I.P. injection of cisplatin, followed by continuation of melatonin for further 10 days. Testicular sections were subjected to H&E, immunohistochemical staining for anti-inducible nitric oxide synthase (iNOS) and anti-androgen receptor (AR). The study proved the protective effect of melatonin against testicular toxicity, when administered prior to and concomitant with cisplatin therapy; confirming the anti-oxidant potential of melatonin |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cisplatin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Melatonin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Rat testis |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mira Farouk Youssef , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Noha Mohamed Afifi Amin , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Soheir Assaad Filobbos , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.16.Ph.D.2017.Kh.P | 01010110074094000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.16.Ph.D.2017.Kh.P | 01020110074094000 | 22.09.2023 | CD - Rom | 74094.CD |