Role of glutathione -S-transferase Omega gene polymorphisms in childhood acute lymphoblastic leukemia / (Record no. 64782)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03347cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031922.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180201s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.Ph.D.2017.Wa.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Wael Mohamed Nabil Mahmoud |
| 245 10 - TITLE STATEMENT | |
| Title | Role of glutathione -S-transferase Omega gene polymorphisms in childhood acute lymphoblastic leukemia / |
| Statement of responsibility, etc. | Wael Mohamed Nabil Mahmoud ; Supervised Hanaa Hamed Arnaout , Emad Nabil Ebeid , Shahira Kamal Anis |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الاشكال المتعددة لجين الجلوتاثيون ترانسفيراز أوميجا وأشتراكها مع خطر سرطان الدم الليمفاوي الحاد فى مرحلة الطفولة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Wael Mohamed Nabil Mahmoud , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 146 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Purpose The aim of our study was to investigate the role of genetic polymorphisms in Glutathione S-transferase Omega (GSTO1 and GSTO2) genes in childhood acute lymphoblastic leukemia susceptibility, and their impact on prognosis of childhood ALL patients . Methods The polymorphism of GSTO1 and GSTO2 genes were analyzed in 96 ALL patients compared with 96 healthy Egyptian children by PCR-based restriction fragment length polymorphism (RFLP) analysis. Results Genotyping of the GSTO1gene revealed no statistically significant difference in genotypes distribution between patients and control groups (p=0.106). However, when ALL cases were divided into de novo and remission groups,it was found that the frequency of homozygous and heterozygous GSTO1 mutations was significantly higher in the de novo group compared to the control group[63.0%vs 43.4% respectively, p=0.028, OR(95%CI):2.222(1.083-4.558)]. As regards The GSTO2 gene, our study demonstrated a statistically significant difference in genotypes distribution between patients and control groups; the frequency of the homozygous GSTO2 mutation was significantly higher in the de novo group compared to healthy subjects (17.3%vs 2.0%, p= 0.002 ).In addition ,the frequency of the homozygous and heterozygous GSTO2 mutation was significantly higher in the remission group compared to the control group [(82.0%vs 63.6%, p=0.012, OR(95% CI)=2.929(1.238- 6.929)]. No association was found between the presence of GSTO1 or GSTO2 mutation or their combined presence and the available bad prognostic factors (age>10 years, T-ALL phenotype, WBCs more than 50.000x10⁹/L) Conclusion We concluded that polymorphisms in the GSTO1 and O2 genes allele are present in an increased percentage of Childhood acute lymphoblastic leukemia patients. Thus it might play an important role as a genetic risk factor in development of ALL in Egyptian children |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | ALL |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | GSTO genes |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pediatrics |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Emad Nabil Ebeid , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanaa Hamed Arnaout , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shahira Kamal Anis , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.Ph.D.2017.Wa.R | 01010110074221000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.Ph.D.2017.Wa.R | 01020110074221000 | 22.09.2023 | CD - Rom | 74221.CD |