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Role of glutathione -S-transferase Omega gene polymorphisms in childhood acute lymphoblastic leukemia / (Record no. 64782)

MARC details
000 -LEADER
fixed length control field 03347cam a2200349 a 4500
003 - CONTROL NUMBER IDENTIFIER
control field EG-GiCUC
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250223031922.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 180201s2017 ua dh f m 000 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency EG-GiCUC
Language of cataloging eng
Transcribing agency EG-GiCUC
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title eng
049 ## - LOCAL HOLDINGS (OCLC)
Holding library Deposite
097 ## - Thesis Degree
Thesis Level Ph.D
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
Classification number Cai01.11.07.Ph.D.2017.Wa.R
100 0# - MAIN ENTRY--PERSONAL NAME
Personal name Wael Mohamed Nabil Mahmoud
245 10 - TITLE STATEMENT
Title Role of glutathione -S-transferase Omega gene polymorphisms in childhood acute lymphoblastic leukemia /
Statement of responsibility, etc. Wael Mohamed Nabil Mahmoud ; Supervised Hanaa Hamed Arnaout , Emad Nabil Ebeid , Shahira Kamal Anis
246 15 - VARYING FORM OF TITLE
Title proper/short title الاشكال المتعددة لجين الجلوتاثيون ترانسفيراز أوميجا وأشتراكها مع خطر سرطان الدم الليمفاوي الحاد فى مرحلة الطفولة
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Cairo :
Name of publisher, distributor, etc. Wael Mohamed Nabil Mahmoud ,
Date of publication, distribution, etc. 2017
300 ## - PHYSICAL DESCRIPTION
Extent 146 P. :
Other physical details charts , facsimiles ;
Dimensions 25cm
502 ## - DISSERTATION NOTE
Dissertation note Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
520 ## - SUMMARY, ETC.
Summary, etc. Purpose The aim of our study was to investigate the role of genetic polymorphisms in Glutathione S-transferase Omega (GSTO1 and GSTO2) genes in childhood acute lymphoblastic leukemia susceptibility, and their impact on prognosis of childhood ALL patients . Methods The polymorphism of GSTO1 and GSTO2 genes were analyzed in 96 ALL patients compared with 96 healthy Egyptian children by PCR-based restriction fragment length polymorphism (RFLP) analysis. Results Genotyping of the GSTO1gene revealed no statistically significant difference in genotypes distribution between patients and control groups (p=0.106). However, when ALL cases were divided into de novo and remission groups,it was found that the frequency of homozygous and heterozygous GSTO1 mutations was significantly higher in the de novo group compared to the control group[63.0%vs 43.4% respectively, p=0.028, OR(95%CI):2.222(1.083-4.558)]. As regards The GSTO2 gene, our study demonstrated a statistically significant difference in genotypes distribution between patients and control groups; the frequency of the homozygous GSTO2 mutation was significantly higher in the de novo group compared to healthy subjects (17.3%vs 2.0%, p= 0.002 ).In addition ,the frequency of the homozygous and heterozygous GSTO2 mutation was significantly higher in the remission group compared to the control group [(82.0%vs 63.6%, p=0.012, OR(95% CI)=2.929(1.238- 6.929)]. No association was found between the presence of GSTO1 or GSTO2 mutation or their combined presence and the available bad prognostic factors (age>10 years, T-ALL phenotype, WBCs more than 50.000x10⁹/L) Conclusion We concluded that polymorphisms in the GSTO1 and O2 genes allele are present in an increased percentage of Childhood acute lymphoblastic leukemia patients. Thus it might play an important role as a genetic risk factor in development of ALL in Egyptian children
530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE
Additional physical form available note Issued also as CD
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term ALL
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term GSTO genes
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Pediatrics
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Emad Nabil Ebeid ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Hanaa Hamed Arnaout ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Shahira Kamal Anis ,
Relator term
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a>
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Nazla
Reviser Revisor
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Shimaa
Reviser Cataloger
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Thesis
Holdings
Source of classification or shelving scheme Not for loan Home library Current library Date acquired Full call number Barcode Date last seen Koha item type Copy number
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة قاعة الرسائل الجامعية - الدور الاول 11.02.2024 Cai01.11.07.Ph.D.2017.Wa.R 01010110074221000 22.09.2023 Thesis  
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة مخـــزن الرســائل الجـــامعية - البدروم 11.02.2024 Cai01.11.07.Ph.D.2017.Wa.R 01020110074221000 22.09.2023 CD - Rom 74221.CD