Investigation of angiotensin 1-7 pathway role on healthy and osteoporotic bone using in vivo model of osteoporosis in rats / (Record no. 65040)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03794cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031930.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180218s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2017.Ha.I |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hatem Mustafa Radwan Abuohashish |
| 245 10 - TITLE STATEMENT | |
| Title | Investigation of angiotensin 1-7 pathway role on healthy and osteoporotic bone using in vivo model of osteoporosis in rats / |
| Statement of responsibility, etc. | Hatem Mustafa Radwan Abuohashish ; Supervised Mahmoud Mohamad Khattab , Dina Sabry Abdelfatah , Salim Salih Alrejaie |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | بحث تأثير الأنجيوتنسين 1-7 على العظام الصحيحة والهشة باستخدام نموذج حي لمرض هشاشة العظام في الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Hatem Mustafa Radwan Abuohashish , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 250 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Osteoporosis is a worldwide epidemiological problem characterized by impaired bone mass and micro-architecture. Recently, the correlation between renin angiotensin system (RAS) and bone structure and metabolism was established. Angiotensin (Ang) II was found to induce bone loss and resorption through its angiotensin type 1 receptor (AT1R). Moreover, RAS inhibitory medications including angiotensin receptors blockers (ARB) and angiotensin converting enzyme inhibitors (ACEI) were found to attenuate this effect. The RAS is more complex than it was initially anticipated and due to several novel components being discovered recently. Ang1-7 is a heptapeptide, endogenous molecule of the RAS, which binds to its G-protein-coupled receptor, Mas receptor, and is considered the beneficial peptide of the RAS. Biological effects of Ang1-7/Mas receptor axis are often opposite to those of the AngII/AT1R axis. Objectives: Accordingly, this study was designed to study the effect of Ang1-7 on healthy and osteoporotic bone. Furthermore, the present study investigated whether the osteoprotective effects of ARB and ACEI are mediatedvia the Ang1-7/Mas receptor axis. Methods: Ovariectomized (OVX) Wistar albino rats were used in the present study as a model for osteoporosis. After 8 weeks of a bilateral ovariectomy and sham operations, animals were divided into 16 groups. With exception of the control groups, OVX and sham animals received (1) Ang1-7, (2) Mas receptor blocker (A-779), (3) Ang1-7+A-779, (4) ARB (losartan), (5) losartan + A-779, (6) ACEI (captopril) and (7) captopril + A-799 for the following six weeks. At the end of treatment period, urine samples were taken then animals were sacrificed to collect serum and femoral bone samples. Bone turnover biomarkers were measured in urine and serum samples using ELISA technique. In addition, femoral bones were used to estimate morphometric parameters by micro-computed tomography (micro-CT). Minerals levels were also determined in digested bone, serum, and urine samples by inductive coupled plasma mass spectroscopy (ICP-MS). Finally, the expressions of different RAS molecules, enzymes and receptors as well as osteoclastogenesis modulating factors were determined in the femur heads using western blot techniques. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Angiotensin 1-7 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Osteoporosis in rats |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Osteoporotic bone |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dina Sabry Abdelfatah , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mahmoud Mohamad Khattab , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Salim Salih Al-Rejaie , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2017.Ha.I | 01010110074368000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2017.Ha.I | 01020110074368000 | 22.09.2023 | CD - Rom | 74368.CD |