MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03239cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
180227s2017 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.33.M.Sc.2017.Di.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dina Mahmoud Mohamed Gabr |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Assessment of response to sofosbuvir-based triple therapy versus sofosbuvir-based dual therapy in chronic HCV treatment experienced patients / |
| Statement of responsibility, etc. |
Dina Mahmoud Mohamed Gabr ; Supervsed Ahmed Fouad Soliman , Marwa Khairy Mehasseb , Rabab Muhamed Maher |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تقيم الاستجابه للعلاج الثلاثي القائم علي عقار السوفوسبفير في مقابل العلاج الثنائي في مرضي الالتهاب الكبدي الفيروسي المزمن (س) الذين سبق لهم العلاج بالانتيرفيرون طويل المفعول و الريبافيرين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Dina Mahmoud Mohamed Gabr, |
| Date of publication, distribution, etc. |
2017 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
73 P. : |
| Other physical details |
charts ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Background: HCV is a major public health in Egypt carrying many complications. Treatment with pegylated interferon and ribavirin was associated with many contraindications and complications as well as modest sustained virological response (SVR). With the emergence of sofosbuvir based treatment regimens the SVR markedly improved even with treatment experienced (pegylated interferon/ribavirin) patients. Aim of the work: Assessment of the response ofsofosbuvir based dual therapy versussofosbuvir based triple therapy in pegylated interferon/ribavirin experienced patients. Patients and methodology: this study was conducted on 200 HCV treatment experienced patients divided into two groups; Group (1): received dual therapy (SOF+RBV) for 24 weeks and group (2): received triple therapy (SOF+RBV+PEG-IFN) for 12 weeks. Both groups were compared regarding baseline characteristics, rapid virological response (RVR), end of treatment response (ETR) and SVR and side effects. Results: Males represented 65% of the studied population (p value 0.003), 14.5% were cirrhotic and 18% were diabetics. Significant drop of serum transaminases level was reported in both groups during the treatment. Significant rise of bilirubin level and decline of hemoglobin were reported with ribavirin use in both groups. RVR (group (1) 95%, group (2) 99%) and ETR (group(1) 98%, group (2) 100%) were comparable in both groups. SVR was significantly higher in group (2)(triple therapy) 96% than group (1) (dual therapy) 79% with p value 0.001. Conclusion: SVR of triple therapy (SOF+RBV+PEG-IFN) for 12 weeks in chronic PEG-IFN and RBV experienced HCV patients is better than dual therapy (SOF+RBV) for 24weeks |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Chronic HCV |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Dual therapy |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Triple therapy |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Ahmed Fouad Soliman , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Marwa Khairy Mehasseb , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Rabab Muhamed Maher , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
