MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02977cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
180227s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.07.Ph.D.2017.Ma.I |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mahmoud Hasanin Elsherbiny |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Impact of CYP3A4-(A290G) and CYP2B6 (G516T) polymorphisms on predisposition and prognosis of acute myeloid leukemia / |
| Statement of responsibility, etc. |
Mahmoud Hasanin Elsherbiny ; Supervsed Nesrine Mohamed Algharbawi , Shahira Kamal Anis , Gihan Hamed Shaheen |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
في التهيئة والتطور المرضى لسرطان الدم النخاعي الحاد CYP3A4 و CYP2B6أثر تعدد الشكل الجيني في جيني |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Mahmoud Hasanin Elsherbiny , |
| Date of publication, distribution, etc. |
2017 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
163 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Background: Several genetic single nucleotide polymorphisms have been determined as possible risk factors for the development of leukemia. CYP3A4 and CYP2B6 are abundant cytochrome P450 enzymes in the human liver. CYP3A4-A-290G and CYP2B6-G516T polymorphisms appear to influence the enzymatic expression and activity in drug metabolism and carcinogen inactivation and have been implicated in AML development. Aims: the study aimed to evaluate the impact of CYP3A4-A-290G and CYP2B6-G516T polymorphisms on the predisposition and prognosis of AML. Methodology: the study included 50 newly diagnosed AML cases and 50 age and sex comparable healthy controls. Detection of CYP3A4-A-290G and CYP2B6-G516T polymorphisms was done by molecular PCR/ RFLP. Results: the main findings were increased frequency of mutant CYP2B6 (homozygous and heterozygous) and CYP3A4 (homozygous and heterozygous) genotypes in AML cases compared to control subjects, increased combined gene mutations in AML patient group compared to control subjects. (43.7% vs 5.0%, p=0.003). There was no statistically significant difference between any of the enzyme polymorphisms and early response to treatment. CYP3A4 mutation was significantly associated with worse overall survival. Significant association was found between both CYP3A4-A-290G and CYP2B6-G516T polymorphisms and development of AML (p-values were 0.006 and 0.017 respectively). Conclusion: these findings suggest a pathogenetic role of these gene polymorphisms in AML and a possible bad prognostic impact of CYP3A4-A-290G polymorphism on disease course |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Acute myeloid leukemia |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
CYP3A4-A-290G |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Gene polymorphism |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Gihan Hamed Shaheen , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Nesrine Mohamed Algharbawi , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Shahira Kamal Anis , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
