MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03325cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
180305s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.07.M.Sc.2017.Ne.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Nesrine Saleh Mohammed Mohammed |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Study of the association of manganese superoxide dismutase gene polymorphism (rs4880) with diabetic retinopathy in a cohort of type II diabetic Egyptian patients / |
| Statement of responsibility, etc. |
Nesrine Saleh Mohammed Mohammed ; Supervised Sarah Mahmoud Elkateb , Hanan Ali Ahmed Madani , Fatma Salah Eldin Abdelmoutagalli |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دراسة العلاقة بين تعدد الأشكال الوراثية في جين إنزيم المنجنيزالمحول للأكسجين التفاعلي واعتلال الشبكية السكري في مرضي النوع الثاني من السكرفي مجموعة من المصريين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Nesrine Saleh Mohammed Mohammed , |
| Date of publication, distribution, etc. |
2017 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
146 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Background:In diabetic retinopathy (DR), the vascular endothelium is damaged due tooxidative stress and inflammation. Manganese superoxide dismutase (MnSOD) is one of the most important enzymesresponsible for the defense against oxidative damage in the mitochondria. A polymorphism in the second exon of theMnSOD gene at 16th amino acid (Ala16Val) in the mitochondrial targeting sequence(MTS) of the protein has been linked to several diseases including DR.This polymorphism affects the scavenger activity of the enzyme andgenerates high reactive oxygen species which could exacerbatethe development of DR. This study aims to investigate the association between Ala16Val MnSODgene polymorphism and the susceptibility to DR in type 2 diabetes patients. Subjects and Methods:150 unrelated patients with type 2 diabetes mellitus were enrolled: 100 patients with diabetic retinopathy (proliferative and non-proliferative) with and without Diabetic Macular Edema(DME) and 50 subjects control group with type 2 diabetes of duration of10yearsandmore who had no clinical signs of diabetic retinopathy.Ala16Val SNP ofMn SOD gene (rs4880) was detected by Taqman real time PCR. Results:No statistically significant difference was found in different genotypes frequency betweenthe DR (-) and DR (+) groups (p=0.3), norbetween the stages ofDR (P=0.245). But in the DR (+) group, the DME (+) group had a higher VV frequency than that of the DME (-) group (P=0.018).Diabetic duration, and insulin therapy were related to DR. Conclusion:Ala16Valpolymorphism ofMn SOD geneis associated with Diabetic Macular Edema (DME) in type 2 diabetes patients butthere is no association between this polymorphism and diabetic retinopathy |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Diabetes Mellitus |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Diabetic Macular Edema |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Diabetic retinopathy |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Fatma Salah Eldin Abdelmoutagalli , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Hanan Ali Ahmed Madani , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Sarah Mahmoud Elkateb , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
