Platelet annexin V and CXCR4 expression inpatients with immune thrombocytopenic purpura / (Record no. 65282)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02822cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031938.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180305s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.M.Sc.2017.He.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hend Mohamed Hassan Mohamed |
| 245 10 - TITLE STATEMENT | |
| Title | Platelet annexin V and CXCR4 expression inpatients with immune thrombocytopenic purpura / |
| Statement of responsibility, etc. | Hend Mohamed Hassan Mohamed ; Supervised Rania Mohamed Fawzy , Aml Soliman Nasr , Noha Mohamed Elhusseiny |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | في مرضى نقص الصفائح المناعى (CXCR4)و (Annexin V)دراسة عن |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Hend Mohamed Hassan Mohamed , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 95 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Immune thrombocytopenia (ITP), also known as idiopathic thrombocytopenic purpura is an acquired autoimmune disorder, characterized by the production of platelet antibodies, resulting in the destruction of platelets and inhibition of their production. Most reports show that these antiplatelet antibodies induce early destruction of platelets by targeting platelets through Fc receptors in the activated reticuloendothelial system, other studies show that they can act by hypothesis of thrombocytopenia resulting from Fc-independent mechanisms via activation of apoptotic signals. These studies also demonstrated that antiplatelet antibodies including thrombocytopenia are associated with increased apoptotic markers of platelet including annexin v. CXCR4, a chemokine receptor for stromal cell-derived factor(SDF-1) is present on the surface of megakaryocytic lineage as well as on the platelet membrane, and the CXCR4/SDF-1 axis plays an important role in polyploidization and transendothelial migration of megakaryocytes favoring platelet production,this CXCR4/SDF-1 interaction triggers many intracellular signals,such as Akt activation which contributes to apoptotic resistance. Recently, decreased CXCR4 expression on platelet surface had been described in patients with essential thrombocytosis, characterized by megakaryocytic hyperplasia and persistent thrombocytosis. Given that studies focused on examining the circumstance of platelets in ITP are limited |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Annexin V |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Immune thrombocytopenic purpura |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | ITP |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Aml Soliman Nasr , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Noha Mohamed Elhusseiny , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rania Mohamed Fawzy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.M.Sc.2017.He.P | 01010110074538000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.M.Sc.2017.He.P | 01020110074538000 | 22.09.2023 | CD - Rom | 74538.CD |