Role of two xanthine oxidase inhibitors "allopurinol and febuxostat" in metabolic syndrome induced experimentally in rats / (Record no. 65553)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03334cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031946.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180324s2017 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.29.M.Sc.2017.Na.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nagwan Mahmoud Salama |
| 245 10 - TITLE STATEMENT | |
| Title | Role of two xanthine oxidase inhibitors "allopurinol and febuxostat" in metabolic syndrome induced experimentally in rats / |
| Statement of responsibility, etc. | Nagwan Mahmoud Salama ; Supervised Amani Nabil Shafik , Eman Hassan Abdelrahman , George Nazih Bishara |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دور اثنين من مثبطات أوكسيديز الزانثين "الوبيورينول وفبيوكسوستات" في متلازمة التمثيل الغذائي المحدثة تجريبياً في الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nagwan Mahmoud Salama , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 127 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pharmacology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: Metabolic syndrome is a cluster of metabolic risk factors that promote the development of diabetes and cardiovascular disease.Recent epidemiological studies have linked the prevalence of metabolic syndrome with increasing serum uric acid levels. Elevated serum uric acid level occurring with metabolic syndrome may not only be a consequence of hyperinsulinemia, but also it promotes and aggravates the pathogenesis of metabolic syndrome either directly or due to oxidative stress. We attempt to elucidate the role of uric acid in metabolic syndrome and the role of uric acid lowering agents: allopurinol, febuxostat and both drug combinations to ameliorate manifestations of metabolic syndrome. Materials and Method: After induction of metabolic syndrome in male Sprague Dawley albino rats using high fructose diet for 8 weeks, allopurinol, febuxostat and both drug combinations were given orally for 4 weeks at a dose (20mg/kg/day) and (5mg/kg/day) respectively. Systolic blood pressure was measured non-invasively using a rat tail sphygmomanometer. The body weight was taken on weekly basis using the electronic weighing scale. Blood samples were collected for estimation of serum levels of different metabolic parameters. In vitro study on the aortic vascular integrity was performed Result: The current study revealed that hyperuricemia contributes to development of metabolic syndrome. Urate lowering agents showed remarkable improvement in features of metabolic syndrome and this improvement is secondary to reduction in the serum uric acid levels. Conclusion: A significant difference was observed between allopurinol , febuxostat and both drug combinations on lowering the serum uric acid level , markers of oxidative stress and fasting hyperglycemia but there was no great difference between them in management of other features of the syndrome |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Allopurinol |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Febuxostat |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Metabolic syndrome |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amani Nabil Shafik , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Eman Hassan Abdelrahman , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | George NazihBishara , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.29.M.Sc.2017.Na.R | 01010110074668000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.29.M.Sc.2017.Na.R | 01020110074668000 | 22.09.2023 | CD - Rom | 74668.CD |