Interleukin-1Ý and interleukin-6 gene polymorphisms in sickle cell disease patients / (Record no. 65929)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02911cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031957.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180417s2017 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.M.Sc.2017.Ya.I |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Yasmine Rabie Hashem Youssef Elammary |
| 245 10 - TITLE STATEMENT | |
| Title | Interleukin-1Ý and interleukin-6 gene polymorphisms in sickle cell disease patients / |
| Statement of responsibility, etc. | Yasmine Rabie Hashem Youssef Elammary ; Supervised Shahira Zayed , Mona Elghamrawy , Nadia Ibrahim Sewelam |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | فى مرضى أنيميا الخلايا المنجليه Interleukin-1Ý and interleukin-6 التغيّرات الجينيه فى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Yasmine Rabie Hashem Youssef Elammary , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 184 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Sickle cell disease (SCD) is a disorder characterized by a heterogeneous clinical outcome. In the present study, we investigated the associations between Interleukin-1Ý (IL-1Ý) +3954 C>T and Interleukin-6 (IL-6) (-174G>C and -597 G>A) gene polymorphisms and clinical and laboratory data in SCD patients. Methods: The study was conducted on 100 SCD patients (59 sickle cell anemia patients 2SS3 and 41 sickle beta thalassemia patients 2SÝ3). Fifty age and sex matched healthy volunteers were included in the current study as a control group. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) technique was performed for the detection of IL-1Ý and IL-6 gene mutations. Results: In the present work, the homomutant genotypes of IL-1Ý (+3954 C>T), IL-6 (-174G>C) and IL-6 (-597 G>A) were higher in SS patients when compared to control group but with no significant differences. These genotypes were also higher in SS patients when compared to SÝ patients with no significant differences. As regards the clinical complications, the mutant genotypes of IL-1Ý (+3954 C>T) had a higher frequency of splenomegaly in SÝ patients. The mutant genotypes of IL-6 (-174G>C) and IL-6 (-597 G>A) had a higher frequency of leg ulcers in SS patients. Conclusion: From these results we can conclude that IL-1Ý (+3954 C>T), IL-6 (-174G>C) and IL-6 (-597G>A) polymorphisms are not associated with susceptibility to the disease; however, they are associated with some SCD complications |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Interleukin-1Ý |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Interleukin-6 gene |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Sickle cell disease patients |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mona Elghamrawy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nadia Ibrahim Sewelam , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shahira Zayed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.M.Sc.2017.Ya.I | 01010110074924000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.M.Sc.2017.Ya.I | 01020110074924000 | 22.09.2023 | CD - Rom | 74924.CD |