Modulatory effect of certain drugs on diabetic cardiovascular complications in rats / (Record no. 65934)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03029cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031958.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180418s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2017.Ne.M |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nesma Ahmed Abdelrahman Mohamed Shiha |
| 245 10 - TITLE STATEMENT | |
| Title | Modulatory effect of certain drugs on diabetic cardiovascular complications in rats / |
| Statement of responsibility, etc. | Nesma Ahmed Abdelrahman Mohamed Shiha ; Supervised Amina Salem Attia , Lamiaa Ahmed Ahmed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تعديل تأثير أدوية معينة فى المضاعفات القلبية الوعائية لمرض السكر فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nesma Ahmed Abdelrahman Mohamed Shiha , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 221 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The current study aimed to investigate the possible beneficial effects of saxagliptin and escitalopram each alone or in combination on metabolic changes and cardiac complications in type 2 diabetic rats. Diabetes was induced by feeding the rats HFFD for 8 weeks followed by a subdiabetogenic dose of STZ (35 mg/kg, i.p.). Treatment with saxagliptin (10 mg/kg; p.o.) and escitalopram (10 mg/kg; p.o.) alone or in combination was continued for 4 weeks. At the end of the experiment, blood samples were collected for determination of serum parameters (glucose, insulin, fructosamine, HOMA-IR, TGs and TC). Animals were then euthanized and heart samples were collected for biochemical determinations (RAGE, NADPH oxidase, TAC, NF-mB, TNF-Ü, TGF-Ý1, caspase-8, p53, Ü-MHC, Ý-MHC and connexin-43) as well as histopathological examination. The HFFD/STZ model resulted in disturbances in both glycemic and lipid profiles along with an increase in BW. The model also induced myocardial damage that was evident by the increased oxidative stress, inflammation, fibrosis, apoptosis and hypertrophy as well as reduced conduction and contractility. Both saxagliptin and escitalopram alleviated the HFFD/STZ-induced metabolic and cardiac derangements. Combining both drugs promoted additional decreases in serum insulin, fructosamine and TC levels. Moreover, the combined regimen provided further improvement in controlling the diabetic-induced oxidative stress, inflammation, fibrosis, hypertrophy and contractility dysfunction which could be related to the reduction in RAGE content. Escitalopram thus could be considered a favorable antidepressant option in diabetic patients |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cardiovascular complications |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Diabetes mellitus |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Diabetic cardiomyopathy |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amina Salem Attia , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lamiaa Ahmed Ahmed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2017.Ne.M | 01010110074882000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2017.Ne.M | 01020110074882000 | 22.09.2023 | CD - Rom | 74882.CD |