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Chromosome 20q deletion as a structural aberration in philadelphia positive-chronic myeloid leukemia / (Record no. 66181)

MARC details
000 -LEADER
fixed length control field 02840cam a2200349 a 4500
003 - CONTROL NUMBER IDENTIFIER
control field EG-GiCUC
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250223032005.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 180512s2017 ua dh f m 000 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency EG-GiCUC
Language of cataloging eng
Transcribing agency EG-GiCUC
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title eng
049 ## - LOCAL HOLDINGS (OCLC)
Holding library Deposite
097 ## - Thesis Degree
Thesis Level Ph.D
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
Classification number Cai01.11.07.Ph.D.2017.Ri.C
100 0# - MAIN ENTRY--PERSONAL NAME
Personal name Riham Ali Gad
245 10 - TITLE STATEMENT
Title Chromosome 20q deletion as a structural aberration in philadelphia positive-chronic myeloid leukemia /
Statement of responsibility, etc. Riham Ali Gad ; Supervised Hala Mohamed Farawila , Hamdi Mohamed Zawam , Manal M. Mahmoud Makhlouf
246 15 - VARYING FORM OF TITLE
Title proper/short title محو كروموزوم 20 كيو كخلل شكلي في مرضي فيلادلفيا موجب سرطان الدم الميلودي المزمن
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Cairo :
Name of publisher, distributor, etc. Riham Ali Gad ,
Date of publication, distribution, etc. 2017
300 ## - PHYSICAL DESCRIPTION
Extent 161 P. :
Other physical details charts , facsimiles ;
Dimensions 25cm
502 ## - DISSERTATION NOTE
Dissertation note Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
520 ## - SUMMARY, ETC.
Summary, etc. In Philadelphia-positive CML, abnormalities of chromosome 20 were detected, which were associated, in the majority of cases, with clonal evolution and disease progression to accelerated phase or blastic crisis.Our work aimed to study the prevalence of chromosome 20q aberrations in an Egyptian cohort ofPh-positive CML and to evaluate the correlation of these genetic defects with the clinical presentation, laboratory data, disease progression and evolution into accelerated phase or blastic crisis, treatment outcome as well as overall survival. FISH technique was used to detect abnormalities of chromosome 20qin thirty philadelphia-positive CML patients and fifteen age and sex matched normal healthy individuals as a control group. Our study revealed that 14/30Ph-positive CML patients (47%) had aberrations of chromosome 20q. Nine of the thirty patients (30%) had del 20q12. Trisomy 20q was found in 5/30 patients (17%). These cytogenetic abnormalities were associated with significant increased risk of the evolution phase in CML and had a significant shorter total free survival and overall survival as well as a highly significant higher incidence of unfavorable treatment outcome in all phases. In conclusion, these genomic aberrations of chromosome 20q can play an important role in the pathophysiology, development, clinical presentation, laboratory data, disease progression and treatment outcome as well as overall survival in Ph-positive CML patients
530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE
Additional physical form available note Issued also as CD
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term 20q12 deletion
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term FISH
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Ph-positive CML
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Hala Mohamed Farawila ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Hamdi Mohamed Zawam ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Manal M. Mahmoud Makhlouf ,
Relator term
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a>
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Nazla
Reviser Revisor
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Shimaa
Reviser Cataloger
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Thesis
Holdings
Source of classification or shelving scheme Not for loan Home library Current library Date acquired Full call number Barcode Date last seen Koha item type Copy number
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة قاعة الرسائل الجامعية - الدور الاول 11.02.2024 Cai01.11.07.Ph.D.2017.Ri.C 01010110075025000 22.09.2023 Thesis  
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة مخـــزن الرســائل الجـــامعية - البدروم 11.02.2024 Cai01.11.07.Ph.D.2017.Ri.C 01020110075025000 22.09.2023 CD - Rom 75025.CD