Chromosome 20q deletion as a structural aberration in philadelphia positive-chronic myeloid leukemia / (Record no. 66181)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02840cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032005.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180512s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.Ph.D.2017.Ri.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Riham Ali Gad |
| 245 10 - TITLE STATEMENT | |
| Title | Chromosome 20q deletion as a structural aberration in philadelphia positive-chronic myeloid leukemia / |
| Statement of responsibility, etc. | Riham Ali Gad ; Supervised Hala Mohamed Farawila , Hamdi Mohamed Zawam , Manal M. Mahmoud Makhlouf |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | محو كروموزوم 20 كيو كخلل شكلي في مرضي فيلادلفيا موجب سرطان الدم الميلودي المزمن |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Riham Ali Gad , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 161 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | In Philadelphia-positive CML, abnormalities of chromosome 20 were detected, which were associated, in the majority of cases, with clonal evolution and disease progression to accelerated phase or blastic crisis.Our work aimed to study the prevalence of chromosome 20q aberrations in an Egyptian cohort ofPh-positive CML and to evaluate the correlation of these genetic defects with the clinical presentation, laboratory data, disease progression and evolution into accelerated phase or blastic crisis, treatment outcome as well as overall survival. FISH technique was used to detect abnormalities of chromosome 20qin thirty philadelphia-positive CML patients and fifteen age and sex matched normal healthy individuals as a control group. Our study revealed that 14/30Ph-positive CML patients (47%) had aberrations of chromosome 20q. Nine of the thirty patients (30%) had del 20q12. Trisomy 20q was found in 5/30 patients (17%). These cytogenetic abnormalities were associated with significant increased risk of the evolution phase in CML and had a significant shorter total free survival and overall survival as well as a highly significant higher incidence of unfavorable treatment outcome in all phases. In conclusion, these genomic aberrations of chromosome 20q can play an important role in the pathophysiology, development, clinical presentation, laboratory data, disease progression and treatment outcome as well as overall survival in Ph-positive CML patients |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | 20q12 deletion |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | FISH |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ph-positive CML |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Mohamed Farawila , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hamdi Mohamed Zawam , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Manal M. Mahmoud Makhlouf , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.Ph.D.2017.Ri.C | 01010110075025000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.Ph.D.2017.Ri.C | 01020110075025000 | 22.09.2023 | CD - Rom | 75025.CD |