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Synthesis and biological evaluation of novel heterocyclic compounds as antimicrobial and/or anticancer agents / (Record no. 66182)

MARC details
000 -LEADER
fixed length control field 02887cam a2200337 a 4500
003 - CONTROL NUMBER IDENTIFIER
control field EG-GiCUC
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250223032005.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 180512s2017 ua f m 000 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency EG-GiCUC
Language of cataloging eng
Transcribing agency EG-GiCUC
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title eng
049 ## - LOCAL HOLDINGS (OCLC)
Holding library Deposite
097 ## - Thesis Degree
Thesis Level M.Sc
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
Classification number Cai01.12.02.M.Sc.2017.Na.S
100 0# - MAIN ENTRY--PERSONAL NAME
Personal name Nada Sabry Ibraheem Abdelhady
245 10 - TITLE STATEMENT
Title Synthesis and biological evaluation of novel heterocyclic compounds as antimicrobial and/or anticancer agents /
Statement of responsibility, etc. Nada Sabry Ibraheem Abdelhady ; Supervised Ismail Abdelshafy Abdelhamid , Magda Fikry Mahmoud Mohamed
246 15 - VARYING FORM OF TITLE
Title proper/short title التحضير و التقييم البيولوجى لمركبات غير متجانسة الحلقة الجديدة كمضادات للميكروبات و/ أو مضادات للسرطان
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Cairo :
Name of publisher, distributor, etc. Nada Sabry Ibraheem Abdelhady ,
Date of publication, distribution, etc. 2017
300 ## - PHYSICAL DESCRIPTION
Extent 122 P. ;
Dimensions 25cm
502 ## - DISSERTATION NOTE
Dissertation note Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry
520 ## - SUMMARY, ETC.
Summary, etc. Novel bis (1,4-dihydropyridine) derivatives linked to aliphatic or aromatic core via ester as well as ether linkages7-16 were prepared, and confirmed by several spectral tools. The prepared compounds showed better cytotoxicity results against A549 than MCF7. The computational studies showed that compound 9 is binding to xIAP and cIAP1 with good energy score. With respect to the antibacterial activity, compound 14 exhibit the most efficiency one against the studied bacterial strains and hence it is used in the docking study on Ý-ketoacyl-ACP synthaseIII (fabH). The results showed good interaction of compound 14 with fabH. Four compounds were chosen for molecular studies on A549 cell line. The molecular data showed that all compounds caused cell cycle arrest at G1 phase and slightly increased the percentage of early apoptosis with no detectable DNA ladder characteristic of apoptotic cell death. The four compounds induced the up regulation of Bax gene and the down regulation of P53and Bcl2 genes. The activity of caspase 3 was slightly higher than control for compounds 10 and 16 and slightly lower than control for compounds 11 and 15. We also studied the effect of compound 11 on normal cell line (HFB4) after it's treatment with genotoxic factor (H₂ O₂) and we noticed that compound 11 reduces DNA damaging effect of H₂ O₂. So, the new compounds have limited side effects on normal cells and could be used as complementary drugs to reduce the harmful effects of other chemotherapeutic agent
530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE
Additional physical form available note Issued also as CD
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term A549
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Bis 1,4-dihydropyridine
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term MCF7
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Ismail Abdelshafy Abdelhamid ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Magda Fikry Mahmoud Mohamed ,
Relator term
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a>
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Nazla
Reviser Revisor
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Samia
Reviser Cataloger
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Thesis
Holdings
Source of classification or shelving scheme Not for loan Home library Current library Date acquired Full call number Barcode Date last seen Koha item type Copy number
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة قاعة الرسائل الجامعية - الدور الاول 11.02.2024 Cai01.12.02.M.Sc.2017.Na.S 01010110075054000 22.09.2023 Thesis  
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة مخـــزن الرســائل الجـــامعية - البدروم 11.02.2024 Cai01.12.02.M.Sc.2017.Na.S 01020110075054000 22.09.2023 CD - Rom 75054.CD