Synthesis and biological evaluation of novel heterocyclic compounds as antimicrobial and/or anticancer agents / (Record no. 66182)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02887cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032005.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180512s2017 ua f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.02.M.Sc.2017.Na.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nada Sabry Ibraheem Abdelhady |
| 245 10 - TITLE STATEMENT | |
| Title | Synthesis and biological evaluation of novel heterocyclic compounds as antimicrobial and/or anticancer agents / |
| Statement of responsibility, etc. | Nada Sabry Ibraheem Abdelhady ; Supervised Ismail Abdelshafy Abdelhamid , Magda Fikry Mahmoud Mohamed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التحضير و التقييم البيولوجى لمركبات غير متجانسة الحلقة الجديدة كمضادات للميكروبات و/ أو مضادات للسرطان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nada Sabry Ibraheem Abdelhady , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 122 P. ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Novel bis (1,4-dihydropyridine) derivatives linked to aliphatic or aromatic core via ester as well as ether linkages7-16 were prepared, and confirmed by several spectral tools. The prepared compounds showed better cytotoxicity results against A549 than MCF7. The computational studies showed that compound 9 is binding to xIAP and cIAP1 with good energy score. With respect to the antibacterial activity, compound 14 exhibit the most efficiency one against the studied bacterial strains and hence it is used in the docking study on Ý-ketoacyl-ACP synthaseIII (fabH). The results showed good interaction of compound 14 with fabH. Four compounds were chosen for molecular studies on A549 cell line. The molecular data showed that all compounds caused cell cycle arrest at G1 phase and slightly increased the percentage of early apoptosis with no detectable DNA ladder characteristic of apoptotic cell death. The four compounds induced the up regulation of Bax gene and the down regulation of P53and Bcl2 genes. The activity of caspase 3 was slightly higher than control for compounds 10 and 16 and slightly lower than control for compounds 11 and 15. We also studied the effect of compound 11 on normal cell line (HFB4) after it's treatment with genotoxic factor (H₂ O₂) and we noticed that compound 11 reduces DNA damaging effect of H₂ O₂. So, the new compounds have limited side effects on normal cells and could be used as complementary drugs to reduce the harmful effects of other chemotherapeutic agent |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | A549 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Bis 1,4-dihydropyridine |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MCF7 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ismail Abdelshafy Abdelhamid , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Magda Fikry Mahmoud Mohamed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.02.M.Sc.2017.Na.S | 01010110075054000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.02.M.Sc.2017.Na.S | 01020110075054000 | 22.09.2023 | CD - Rom | 75054.CD |