Role of circulating miR-182 and miR-150 as noninvasive biomarkers for hepatocellular carcinoma / (Record no. 66218)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03404cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032006.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180516s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.Ph.D.2017.He.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hend Hamed abdellatif Tamim |
| 245 10 - TITLE STATEMENT | |
| Title | Role of circulating miR-182 and miR-150 as noninvasive biomarkers for hepatocellular carcinoma / |
| Statement of responsibility, etc. | Hend Hamed abdellatif Tamim ; Supervised Noha Mohamed Hosni Shaheen , Naglaa Ali Zayed , Rania Hassan khalifa |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دورهما كدلالات لسرطان الكبد miR-15omiR-182 أهمية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Hend Hamed abdellatif Tamim , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 182 P. : |
| Other physical details | charts , facimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Hepatocellular carcinoma is one of the most common prevalent cancers worldwide. The incidence is highest where hepatitis C and hepatitis B are endemic. Hepatitis C virus is an independent risk factor for chronic hepatitis, liver cirrhosis, HCC and a major reason for liver transplantation. Current diagnostic methods show poor performance. Although serum Alpha fetoprotein has mainly been used for diagnosis and monitoring of HCC, its sensitivity and specificity are still not satisfying. Sensitive and specific cancer biomarkers are essential for early detection and diagnosis of HCC. MicroRNAs have been reported to be promising biomarkers for diagnosing cancers. This study was conducted to detect the role of miR-182 and miR-150 in diagnosis of HCC. Methods: The expression of miR-182 and miR-150 was evaluated using real-time quantitative RT-PCR in 120 patients: 40 HCC patients, 40 hepatitis C patients (20 cirrhotic and 20 non-cirrhotic) and 40 healthy controls. Results: Statistically significant down regulation of miR-182 and miR-150 in HCC when compared to HCV non-cirrhotic group (p=0.015, p=0.006 repectively). Statistically significant reduction of miR-150 in HCC when compared to the control (p=0.039). Statistically significant down regulation of miR-182 and miR-150 in HCV cirrhotic when compared to HCV non-cirrhotic group (p=0.003, p=0.024 respectively). Finally statistically significant upregulation of miR-182 in HCV non-cirrhotic when compared to the control (p=0.036). AFP at the cut-off value of 400 ng/ml showed sensitivity 15% for HCC. The capability for differential diagnosis of HCC and HCV non-cirrhotic was analyzed by combining miR-182, miR-150 and AFP and this resulted in improved sensitivity (90%) and increased diagnostic accuracy (80%) Conclusion: miR-182 and miR-150 can be used as non invasive biomarkers for hepatocellular carcinoma as well as predictive markers for detection of cirrhosis progression in HCV infected patients. miR-182 may also be useful as circulatory marker for HCV infection |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatitis C virus |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatocellular carcinoma |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | miR-182 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Naglaa Ali Zayed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Noha Mohamed Hosni Shaheen , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rania Hassan khalifa , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.Ph.D.2017.He.R | 01010110075033000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.Ph.D.2017.He.R | 01020110075033000 | 22.09.2023 | CD - Rom | 75033.CD |