MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02704cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
180531s2017 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.33.Ph.D.2017.Wa.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Walied Khalid Nasr Elhossary |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Evaluation of the pattern of EPIYA motifs in the Helicobacter pylori CagA gene in Egyptian patients / |
| Statement of responsibility, etc. |
Walied Khalid Nasr Elhossary ; Supervised Rabab Fouad Emam Omar , Walied Fouad Fath Allah , Mohamed Ibrahim Seif Elnasr |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
للبكتيريا الحلزونيه فى المرضى المصريين (CagA) فى جين (EPYIA) تقييم أنماط |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Walied Khalid Nasr Elhossary , |
| Date of publication, distribution, etc. |
2017 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
99 P. : |
| Other physical details |
charts ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Background and Aims: The Helicobacter pylori CagA gene is a major virulence factor that plays an important role in gastroduodenal pathologies. CagA gene undergoes tyrosine phosphorylation in a region containing differing numbers of repeat sequences (EPIYAs), which can result in a modulation of the inflammatory response. The aim of this study is to determine the distribution of the different EPIYA motifs in an Egyptian population for the first time and to detect any possible correlation with the different gastroduodenal pathologies. Patients and Methods: Gastric biopsies were collected from 121 patients with gastritis, duodenal ulcer (DU), gastric ulcer (GU), and gastric cancer or precancerous lesions. H. pylori was detected in 58 biopsies by PCR, then CagA gene in 33 isolates. Finally, The EPIYA motif genotyping was determined and statistical analysis was done to determine any possible correlations. Results: Out of the 33 Cag A positive strains, EPIYA-ABC was the most presented pattern in 23 isolates (69.7%) and the least common pattern was EPIYA-ABCCC, which was positive only in two cases (6.1%). Both EPIYA-AB and EPIYA-ABCC were presented in 4 strains for each (12.1% for each). There were significant statistical correlations between presence of Cag A gene and both PUD and GU, beside correlation between no more than one EPIYA-C motif group and chronic non-atrophic gastritis |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Cag A |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
EPIYA pattern |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Helicobacter pylori |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed Ibrahim Seif Elnasr , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Rabab Fouad Emam Omar , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Walied Fouad Fath Allah , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samia |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
