Association of serum IL-6 Level and its -174 G/C promoter polymorphism with clinical and laboratory characteristics of rheumatoid arthritis patients in Cairo University Hospitals / (Record no. 66441)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03736cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032012.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180602s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.19.Ph.D.2017.Re.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Reham Mohamed Raafat Hamed |
| 245 10 - TITLE STATEMENT | |
| Title | Association of serum IL-6 Level and its -174 G/C promoter polymorphism with clinical and laboratory characteristics of rheumatoid arthritis patients in Cairo University Hospitals / |
| Statement of responsibility, etc. | Reham Mohamed Raafat Hamed ; Supervised Soliman Aref Mohamed , Reham Ali Dwedar , Yasmine Samy Elkholy |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الخاص به في مرضي التهاب المفاصل الروماتويدى مع الخصائص السريرية والمختبرية للمرض في مستشفيات جامعة القاهرة في المصل والتعدد الجيني في المحفز 174جى/سى إرتباط مستوى 6آى إل |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Reham Mohamed Raafat Hamed , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 106 P. : |
| Other physical details | charts , facsimi ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Microbiology and Immunology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background:Rheumatoid arthritis (RA) is a chronic progressive systemic inflammatory autoimmune disease of the joints, which can lead to long term joint damage, resulting in chronic pain, loss of function, and disability. Interleukin-6 (IL-6) encodes a cytokine protein, which causesinflammation, maintains immune homeostasis and plays an essentialrole in RA pathogenesis and IL-6 -174 G/C promoter polymorphism may play a role in susceptibility of RA. Aim of the work: To evaluate the clinical significance of serum levels of interleukin-6 (IL-6) and its-174 G/C promoter polymorphism in Rheumatoid arthritis (RA) patients and to compare with the controls. Patients and methods:This study enrolled 25 RA patients and 25 age and gender matched healthy controls. Demographic, clinical and serological data were prospectively evaluated. Disease activity score (DAS28) and radiological data were assessed. Serum IL-6 level was measured and promoter (-174G/C) genotyped. Results: Serum IL-6 levels were significantly higher in RA patients compared to the controls(pvalue = 0.001), especially those with CC promoter polymorphism. There was a significant correlation between IL-6 and duration of morning stiffness,disease activity,hemoglobin and ESR level. Fifteen patients had GG IL-6 (-174 G/G) gene promoter polymorphism, 8 were GC and 2 CC. ALL controls were GG. There wassignificant association between gene polymorphism and age at disease onset.The age at disease onset(p= 0.0172) was older in those with GG genotype (38.5± 10.25 years), 33.5 ±.71 years in those with CC genotype and was younger in with GC genotype (27.9± 7.9 years). None of the other studied parameters would predict the IL-6 promoter polymorphism. Conclusion:Serum IL-6 levels and -174 G/C promoter polymorphism were higher in RA patients than in healthy controls. The positive correlation of IL-6 with the DAS28 andduration of morning stiffness may confirm its{u2019} increased involvement in the pathogenesis of RA and may point to the need for considering of anti-IL-6 agents in their management plan |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | (-174 G/C) Promoter polymorphism |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | IL-6 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Rheumatoid arthritis |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Reham Ali Dwedar , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Soliman Aref Mohamed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yasmine Samy Elkholy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.19.Ph.D.2017.Re.A | 01010110075153000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.19.Ph.D.2017.Re.A | 01020110075153000 | 22.09.2023 | CD - Rom | 75153.CD |