Evaluation of bioactivity and anticancer properties of moringa oleifera on different cancer cell lines / (Record no. 66624)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03785cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032018.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180624s2017 ua o f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.21.M.Sc.2017.Wa.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Walaa Hesham Aboelyazed Ali |
| 245 10 - TITLE STATEMENT | |
| Title | Evaluation of bioactivity and anticancer properties of moringa oleifera on different cancer cell lines / |
| Statement of responsibility, etc. | Walaa Hesham AboElyazed Ali ; Supervised Mahmoud Ahmed Amer , Wafaa Abdallah Ahmed , Farid A. AbuBedair kashwaa |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | {uFE97}{uFED8}{uFEF4}{uFEF4}{uFEE2} ا{uئإؤئ}{uئإإ٨}{uئإآ٨}{uئإ٨إ}ط ا{uئإؤئ}{uئإء٤}{uئإئ٤}{uئإإإ}ى و ا{uئإؤئ}{uئإء٨}{uئإآأ}{uئإ٨إ}{uئإ٨آ}{uئإآء} ا{uئإؤئ}{uئإإ٤}{uئإأ٠}{uئإ٨إ}دة {uئإؤئ}{uئإإ٠}{uئإآ٤}{uئإءإ}{uئإأ٣}{uئإ٨إ}ن {uئإؤئ}{uئإإ٨}{uئإ٩٢}{uئإ٨إ}ت ا{uئإؤئ}{uئإإ٤}{uئإإإ}ر{uئإئ٣}{uئإإ٨}{uئإؤ٠}{uئإ٨إ} او{uئإؤئ}{uئإئ٤}{uئإؤ٤}{uئإءإ}ا {uئإأآ}{uئإإ٠}{uئإئ٠} {uئإإ٣}{uئإء٨}{uئإ٩٨}{uئإإ٠}{uئإؤ٢} {uئإء٧}{uئإأ٤}{uئإإإ}ط ا{uئإؤئ}{uئإء٨}{uئإئأ}{uئإئ٣}{uئإ٨إ} ا{uئإؤئ}{uئإآ٤}{uئإءإ}{uئإأ٣}{uئإ٨إ}{uئإإ٧}{uئإئ٤}{uئإ٩٤} |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Walaa Hesham Aboelyazed Ali , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 108 P. : |
| Other physical details | photographs ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Cancer is a genetic disease it is caused by changes to genes that control the way of cells function, especially cell growth and division. Selection of cancer treatment is affected by various factors including features of the tumor and patients conditions. Many natural products have anti-tumor effects against different types of cancer, where they have different mechanisms of action including cell growth suppression, modulation of cell differentiation and induction of apoptosis. Moringa oleifera (L) is a commonly used in phytotherapy and herbal medicine that have an anti-inflammatory, anti-spasmodic, anti-hypertensive, anti-oxidant, anti-pyretic, anti-ulcer, anti-epileptic, diuretic, cholesterol lowering, renal, anti-diabetic effects and anti-tumor effects. In the present study; Moringa oleifera (L) leaves aqua{u2019}s extract were evaluated for its cytotoxic potentiality against three tumor cell lines; (HepG2, Caco2 and Mcf7). Cytoxic effects of M.O L-WX by MTT assay revealed remarkable dose dependent anti-cancer activity on Caco2 and Mcf7 while lower anticancer activity on HepG2. The IC value were 4 mg /mL and 9 mg /mL fo 50 CaCo2 and McF7 cancer cell lines respectively while it was 19 mg /mL for Hepg2 cells. The molecular mechanism based study revealed an apoptotic effect; this as evaluated by the significant increase in expression of apoptotic molecules FASL of Caco2 and Mcf7 cell lines (p-value=0.001 and 0.005 respectively) when compared to the control of each cell and also the significant increase in the activity of the caspase8 on Caco2 and Mcf7 (p-value =0.029and 0.007 respectively ), caspase9 (p-value=0.01 and 0.0001 respec-tively), and caspase3 activity (p-value=0.008and 0.004 respectively) when compared to its control |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Apoptosis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cytotoxicity |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Moringa oleifera (L) |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Farid A. AbuBedair kashwaa , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mahmoud Ahmed Amer , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wafaa Abdallah Ahmed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.21.M.Sc.2017.Wa.E | 01010110075254000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.21.M.Sc.2017.Wa.E | 01020110075254000 | 22.09.2023 | CD - Rom | 75254.CD |