Study of the possible protective effect of cromolyn nanosystem on experimentally induced colon cancer in rat / (Record no. 66700)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02874cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032020.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180708s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.01.M.Sc.2017.Om.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Omnia Mohammed Nady |
| 245 10 - TITLE STATEMENT | |
| Title | Study of the possible protective effect of cromolyn nanosystem on experimentally induced colon cancer in rat / |
| Statement of responsibility, etc. | Omnia Mohammed Nady ; Supervised Tarek M. Kamal Motawi , Shohda A. Elmaraghy , Aliaa Nabil Emeshad |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة التأثير الوقائى المحتمل لعقار الكرومولين بنظام النانوعلى سرطان القولون المحدث تجريبيا فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Omnia Mohammed Nady , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 144 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc) - Cairo University - Faculty of Pharmacy - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Colorectal cancer (CRC) is the third most common cancer in the world. Cromolyn is a mast cell stabilizer and was proposed as an anticancer agent; however its high polarity limits its bioavailability by rapid washing from the body. Ten different formulas of cromolyn chitosan nanoparticles (CS NPs) were formulated following ionic gelation technique to improve cromolyn bioavailability. The protective anticancer effect of the optimum formula (F6: size 112.4 nm, charge +39.9 mV, enclosed 93.6% cromolyn and showed a sustained release pattern over 48 hr) were investigated in experimentally-induced CRC rats using dimethylhydrazine (DMH) for 16 weeks. Rats were divided into seven groups, Group 1: Normal control, Group 2: Cromolyn control, Group 3: Cromolyn CS NPs control, Groups 4 to 7 received DMH for 16 weeks to induce CRC. Groups 5 to 7 received cromolyn solution, non-medicated CS NPs and cromolyn CS NPs, respectively as protective treatments. Cromolyn CS NPs significantly reduced colon Akt, Bcl-2, Ý-catenin, GSK-MAP Kinase, NF-{u049B}B P65, and S100P and MDA levels as well as decreased number of aberrant crypt foci compared to DMH group, whereas cromolyn solution decreased colon MDA level only without affecting the other studied parameters. Histopathological examination of colon samples revealed that cromolyn CS NPs exerted an augmented protective anticancer effect by ameliorating tumor pathology compared to cromolyn solution |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Colorectal cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cromolyn |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Dimethylhydrazine |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Aliaa Nabil Emeshad , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shohda Asem Elmaraghy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tarek Mohamed Kamal Motawi , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.01.M.Sc.2017.Om.S | 01010110075298000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.01.M.Sc.2017.Om.S | 01020110075298000 | 22.09.2023 | CD - Rom | 57298.CD |