MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02864cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
180806s2018 ua f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.07.Ph.D.2018.Me.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Menatallah Mohamed Saleh Elaguizy |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Association of miR-18a, miR-21and miR-92a with colorectal carcinoma in a cohort of Egyptian patients / |
| Statement of responsibility, etc. |
Menatallah Mohamed Saleh Elaguizy ; Supervised Ahmed Alsayed Altaweel , Marwa Mohamed Sheta , Ahmed Mostafa Ahmed |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
العلاقة بين ميكرو آر إن ايه 18ا: 21 و 92 ا و سرطان القولون و المستقيم فى مجموعة من المرضى المصريين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Menatallah Mohamed Saleh Elaguizy , |
| Date of publication, distribution, etc. |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
134 P. ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Background: Colorectal cancer (CRC) is a major cause of cancer-related death worldwide. miRNAs have been demonstrated to play an important role in carcinogenesis either by oncogenic or tumor suppressor function. The aim of the present work is to study the serum levels of MiR-21, MiR-92a and MiR-18a to evaluate their potential use as biomarkers of CRC and to correlate their serum levels with the clinicopathological features to detect the prognostic potential of these miRNAs in patients with CRC. Subjects and methods: This study was conducted on 50 patients with CRC and 50 age and sex matched healthy volunteers used as a control group. Determination of the serum relative expression of each of three mature MiRNAs (MiR-21, MiR-92a and MiR-18a) was done after normalization to MiR-16 using the 2-xxCT method. Results: MiR-18a, MiR-21 and MiR-92a were found to be significantly up-regulated in serum of CRC patients (p<0.001, <0.001 and 0.003 respectively) compared to the healthy control group. ROC curve analyses demonstrated areas under the curve (AUC) of 0.906 [95% confidence interval (CI), 0.848{u2011}0.964], with 84% for both sensitivity and specificity for miR-18a, AUC=0.918 [95% CI, 0.866{u2011}0.971], with 84% sensitivity and 90% specificity for miR-21 and AUC=0.672 for miR-92a. Conclusions: MiR{u2011}18a and/or miR{u2011}21 could be helpful biomarkers while serum miR-92a has limited usefulness as a sole biomarker in CRC diagnosis. Combined serum miR-18a and miR-21 showed the highest sensitivity and specificity |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
CRC |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
miR-21 |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
miRNAs |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ahmed Alsayed Altaweel , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ahmed Mostafa Ahmed , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Marwa Mohamed Sheta , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samia |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
