DNA methylation levels of the insulin-like growth factor binding protein 1 gene in type 2 diabetes / (Record no. 66975)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02973cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032028.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180807s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.Ph.D.2017.Sa.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sally Hafez Mohamed Mohamed Hafez |
| 245 10 - TITLE STATEMENT | |
| Title | DNA methylation levels of the insulin-like growth factor binding protein 1 gene in type 2 diabetes / |
| Statement of responsibility, etc. | Sally Hafez Mohamed Mohamed Hafez ; Supervised Hazem Elsayed Abou Youssef , Mona Abdelkader Mohamed , Nehal Salah Hasan |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | فى مرضى داء السكرى من النوع الثانى IGFBP-1 مستوى مثيلة ال دى ان ايه لجين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Sally Hafez Mohamed Mohamed Hafez , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 180 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Type 2 diabetes is a complex trait with both environmental and hereditary factors contributing to the overall pathogenesis. One link between genes, environment, and disease is epigenetics influencing gene transcription and, consequently, organ function. Genome-wide studies have shown altered DNA methylation in tissues important for glucose homeostasis including pancreas, liver, skeletal muscle, and adipose tissue from subjects with type 2 diabetes compared with nondiabetic controls. Factors predisposing for type 2 diabetes including an adverse intrauterine environment, increasing age, overweight, physical inactivity, a family history of the disease, and an unhealthy diet have all shown to affect the DNA methylation pattern in target tissues for insulin resistance in humans. Epigenetics including DNA methylation may therefore improve our understanding of the type 2 diabetes pathogenesis, contribute to development of novel treatments, and be a useful tool to identify individuals at risk for developing the disease. This present study aimed to evaluate IGFBP1 gene methylation levels in peripheral blood of 100 subjects (50 T2DM patients versus 50 healthy controls) and to explore the role of IGFBP1 gene methylation in contribution to individual risk of T2D, using bisulfite pyrosequencing technique to identify IGFBP-1 gene methylation that may be involved in T2DM pathogenesis and prediction of the disease. Methylation of IGFBP-1 gene in T2DM group at each of the six CpG (P%) sites were statistically significant lower than the control group |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | DNA methylation |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | IGFBP-1 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Type 2 diabetes |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hazem Elsayed Abou Youssef , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mona Abdelkader Mohamed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nehal Salah Hasan , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.Ph.D.2017.Sa.D | 01010110075475000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.Ph.D.2017.Sa.D | 01020110075475000 | 22.09.2023 | CD - Rom | 75475.CD |