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DNA methylation levels of the insulin-like growth factor binding protein 1 gene in type 2 diabetes / (Record no. 66975)

MARC details
000 -LEADER
fixed length control field 02973cam a2200349 a 4500
003 - CONTROL NUMBER IDENTIFIER
control field EG-GiCUC
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250223032028.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 180807s2017 ua dh f m 000 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency EG-GiCUC
Language of cataloging eng
Transcribing agency EG-GiCUC
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title eng
049 ## - LOCAL HOLDINGS (OCLC)
Holding library Deposite
097 ## - Thesis Degree
Thesis Level Ph.D
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
Classification number Cai01.11.07.Ph.D.2017.Sa.D
100 0# - MAIN ENTRY--PERSONAL NAME
Personal name Sally Hafez Mohamed Mohamed Hafez
245 10 - TITLE STATEMENT
Title DNA methylation levels of the insulin-like growth factor binding protein 1 gene in type 2 diabetes /
Statement of responsibility, etc. Sally Hafez Mohamed Mohamed Hafez ; Supervised Hazem Elsayed Abou Youssef , Mona Abdelkader Mohamed , Nehal Salah Hasan
246 15 - VARYING FORM OF TITLE
Title proper/short title فى مرضى داء السكرى من النوع الثانى IGFBP-1 مستوى مثيلة ال دى ان ايه لجين
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Cairo :
Name of publisher, distributor, etc. Sally Hafez Mohamed Mohamed Hafez ,
Date of publication, distribution, etc. 2017
300 ## - PHYSICAL DESCRIPTION
Extent 180 P. :
Other physical details charts , facsimiles ;
Dimensions 25cm
502 ## - DISSERTATION NOTE
Dissertation note Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
520 ## - SUMMARY, ETC.
Summary, etc. Type 2 diabetes is a complex trait with both environmental and hereditary factors contributing to the overall pathogenesis. One link between genes, environment, and disease is epigenetics influencing gene transcription and, consequently, organ function. Genome-wide studies have shown altered DNA methylation in tissues important for glucose homeostasis including pancreas, liver, skeletal muscle, and adipose tissue from subjects with type 2 diabetes compared with nondiabetic controls. Factors predisposing for type 2 diabetes including an adverse intrauterine environment, increasing age, overweight, physical inactivity, a family history of the disease, and an unhealthy diet have all shown to affect the DNA methylation pattern in target tissues for insulin resistance in humans. Epigenetics including DNA methylation may therefore improve our understanding of the type 2 diabetes pathogenesis, contribute to development of novel treatments, and be a useful tool to identify individuals at risk for developing the disease. This present study aimed to evaluate IGFBP1 gene methylation levels in peripheral blood of 100 subjects (50 T2DM patients versus 50 healthy controls) and to explore the role of IGFBP1 gene methylation in contribution to individual risk of T2D, using bisulfite pyrosequencing technique to identify IGFBP-1 gene methylation that may be involved in T2DM pathogenesis and prediction of the disease. Methylation of IGFBP-1 gene in T2DM group at each of the six CpG (P%) sites were statistically significant lower than the control group
530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE
Additional physical form available note Issued also as CD
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term DNA methylation
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term IGFBP-1
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Type 2 diabetes
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Hazem Elsayed Abou Youssef ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Mona Abdelkader Mohamed ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Nehal Salah Hasan ,
Relator term
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a>
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Nazla
Reviser Revisor
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Samia
Reviser Cataloger
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Thesis
Holdings
Source of classification or shelving scheme Not for loan Home library Current library Date acquired Full call number Barcode Date last seen Koha item type Copy number
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة قاعة الرسائل الجامعية - الدور الاول 11.02.2024 Cai01.11.07.Ph.D.2017.Sa.D 01010110075475000 22.09.2023 Thesis  
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة مخـــزن الرســائل الجـــامعية - البدروم 11.02.2024 Cai01.11.07.Ph.D.2017.Sa.D 01020110075475000 22.09.2023 CD - Rom 75475.CD