Study of the possible effects of certain beta-adrenergic blockers in experimentally induced hepatorenal syndrome in rats / (Record no. 66998)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03262cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032029.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180808s2018 ua do f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2018.Ah.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Mohamed Alaa Eldin Atwa |
| 245 10 - TITLE STATEMENT | |
| Title | Study of the possible effects of certain beta-adrenergic blockers in experimentally induced hepatorenal syndrome in rats / |
| Statement of responsibility, etc. | Ahmed Mohamed Alaa Eldin Atwa ; Supervised Sanaa Abdelbaky Kenawy , Nemat Ahmed Zakaria Yassin , Rania Mohsen Abdelsalam |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة التأثيرات المحتملة لبعض مقيدات مستقبلات بيتا الأدرينالينية فى المتلازمة الكبدية الكلوية المستحدثة تجريبيا فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ahmed Mohamed Alaa Eldin Atwa , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 228 P. : |
| Other physical details | charts , photographs ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Renal failure occurs in 40{u2013}80% of patients with end stage liver disease and is associated with an unfavourable prognosis. The development of renal failure in the absence of clinical, anatomical or pathological causes of renal failure is termed hepatorenal syndrome (HRS). A single injection of high dose Galactosamine (Gal) in rats can develop functional acute renal failure in addition to acute damage and liver failure with elaboration of a hyperdynamic circulation. So far, no effective strategies are available for the treatment or prevention of HRS. Portal hypertension is an almost unavoidable complication of cirrhosis and provides the driving force for most of its complications. To date, for medical treatment of portal hypertension, beta-blockers are used to decrease splanchnic inflow and may be combined with nitrates to reduce intrahepatic resistance. The present study was performed to investigate the possible protective effects of nebivolol (Nebi) and carvedilol (Carv), the nitric oxide (NO) releasing third generation Ý-blockers with antioxidant, anti-inflammatory and vasodilatory properties in Gal-induced HRS in rats. Six groups of rats were employed in this study. The first and second groups received saline and served as normal group and control groups, respectively. Rats of groups (2-6) received a single dose of Gal solution in sterile saline (1.1 g/kg, i.p.) on the 8th day of the experiment. Groups 3 and 4 received Nebi (10 and 20 mg/kg/day, respectively, p.o.). Groups 5 and 6 received Carv (10 and 20 mg/kg/day, respectively, p.o.). Treatments were carried out for 10 successive days. Blood samples were withdrawn from all rats on day 10, after 2 h of the last drug administration |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Galactosamine |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatorenal syndrome |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Nebivolol |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nemat Ahmed Zakaria Yassin , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rania Mohsen Abdelsalam , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sanaa Abdelbaky Kenawy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2018.Ah.S | 01010110075496000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2018.Ah.S | 01020110075496000 | 22.09.2023 | CD - Rom | 75496.CD |