MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02564cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
180809s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.01.Ph.D.2018.No.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Noha Hussein Sayed |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Epigenetic mechanisms linking obesity to colorectal cancer / |
| Statement of responsibility, etc. |
Noha Hussein Sayed ; Supervised Tarek Mohamed Kamal Motawi , Manal Fouad Ismail , Olfat Gamil Shaker |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
الأليات فوق الوراثية التى تربط السمنة بسرطان القولون و المستقيم |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Noha Hussein Sayed , |
| Date of publication, distribution, etc. |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
132 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Peroxisome proliferator activated receptor gamma (PPARÞ) is a nuclear receptor that is deregulated in obesity. PPARÞ exerts diverse antineoplastic effects. Attempting to determine the clinical relevance of the epigenetic mechanisms controlling the expression PPARÞ and susceptibility to colorectal cancer (CRC) in obese subjects, this study investigated the role of some microRNAs and DNA methylation on the deregulation of PPARÞ. Seventy CRC patients (34 obese and 36 lean), 22 obese and 24 lean healthy controls were included. MicroRNA levels were measured in serum. PPARÞ promoter methylation was evaluated in blood. PPARÞ level was evaluated by measuring mRNA level in blood and protein level in serum. The tested microRNAs 27b, 130b and 138 were significantly upregulated in obese and CRC patients. Obese and CRC patients had significantly low levels of PPARÞ. A significant negative correlation was found between PPARÞ levels and the studied microRNAs. There was a significant PPARÞ promoter hypermethylation in CRC patients that correlated to low PPARÞ levels. Our results suggest that upregulation of microRNAs 27b, 130b and 138 is associated with susceptibility to CRC in obese subjects through PPARÞ downregulation. Hypermethylation of PPARÞ gene promoter is associated with CRC through suppression of PPARÞ regardless of BMI |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Colorectal cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Obesity |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
PPARÞ |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Manal Fouad Ismail , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Olfat Gamil Shaker , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Tarek Mohamed Kamal Motawi , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samia |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
