The prognostic significance of the BMI-1 and BAALC genes in newly diagnosed Egyptian adult acute myeloid leukemia patients / (Record no. 67074)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03443cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032031.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180815s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.19.03.Ph.D.2017.Mo.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mona Shafik Mahmoud Elashry |
| 245 14 - TITLE STATEMENT | |
| Title | The prognostic significance of the BMI-1 and BAALC genes in newly diagnosed Egyptian adult acute myeloid leukemia patients / |
| Statement of responsibility, etc. | Mona Shafik Mahmoud Elashry ; Supervised Ragia Hussein Badawy , Naglaa Mostafa Hassan , Nevine Fawzy Shafik |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | فى حالات السرطان الميلودى الحاد فى المرضى المصريين البالغين و علاقته بالتطور المرضى BAALC و جين ال BMI دراسة جين ال 1 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mona Shafik Mahmoud Elashry , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 198 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim: The aim of this work is to investigate the expression pattern of B-cellspecifics moloney murine Leukemia virus integration site-1 (BMI-1) and brain and acute leukemia, cytoplasmic (BAALC) genes, their prognostic significance and their clinical significance in newly diagnosed Egyptian adult acute myeloid leukemia patients. Patients and Methods: The current study was carried out on 95 newly diagnosed adult (>18) acute myeloid leukemia patients, along with 20 age and sex matched apparently healthy normal controls. BMI-1 and BAALC expression was detected in the bone marrow of both patients and controls using quantitative real-time reverse transcription polymerase chain reaction (RT-PCR) with cut off value set at 50th percentile for both genes. Results: BMI-1 and BAALC expression was detected in 50% of cases but not in any controls. A statistical significant correlation was found between low BMI-1 expressers and hepatomegaly (p-value=0.007) while high BMI-1 expressers tend to have a lower hemoglobin level (<8) (p-value=0.081) and were more likely to be in the favorable cytogenetic risk group (P-value= 0.036). There was a statistically significant correlation between BAALC and age (P-value=0.015). The increase in BAALC expression was significantly associated with lymphadenopathy (p-value=0.043) and CD34 positive cases (p- value= 0.003). In addition, there was a trend of high BAALC expression to be associated with the more immature FAB subtypes (M1/M2) compared to the monocytic differentiated FAB (M4 and M5) (p-value {u2264}0.054). No statistical significance was noted for sex, splenomegaly, other hematological findings and response to treatment except for BAALC gene and response to treatment with a trend of higher death rate among low BAALC expressers and a higher incidence of CR among high BAALC expressers (P-value {u2264} 0.014). No statistical significance in overall survival and disease free survival for both genes was found |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Acute myeloid leukemia |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | AML |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | BMI-1 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Naglaa Mostafa Hassan , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nevine Fawzy Shafik , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ragia Hussein Badawy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.19.03.Ph.D.2017.Mo.P | 01010110075515000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.19.03.Ph.D.2017.Mo.P | 01020110075515000 | 22.09.2023 | CD - Rom | 75515.CD |