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The prognostic significance of the BMI-1 and BAALC genes in newly diagnosed Egyptian adult acute myeloid leukemia patients / (Record no. 67074)

MARC details
000 -LEADER
fixed length control field 03443cam a2200349 a 4500
003 - CONTROL NUMBER IDENTIFIER
control field EG-GiCUC
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250223032031.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 180815s2017 ua dh f m 000 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency EG-GiCUC
Language of cataloging eng
Transcribing agency EG-GiCUC
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title eng
049 ## - LOCAL HOLDINGS (OCLC)
Holding library Deposite
097 ## - Thesis Degree
Thesis Level Ph.D
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
Classification number Cai01.19.03.Ph.D.2017.Mo.P
100 0# - MAIN ENTRY--PERSONAL NAME
Personal name Mona Shafik Mahmoud Elashry
245 14 - TITLE STATEMENT
Title The prognostic significance of the BMI-1 and BAALC genes in newly diagnosed Egyptian adult acute myeloid leukemia patients /
Statement of responsibility, etc. Mona Shafik Mahmoud Elashry ; Supervised Ragia Hussein Badawy , Naglaa Mostafa Hassan , Nevine Fawzy Shafik
246 15 - VARYING FORM OF TITLE
Title proper/short title فى حالات السرطان الميلودى الحاد فى المرضى المصريين البالغين و علاقته بالتطور المرضى BAALC و جين ال BMI دراسة جين ال 1
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Cairo :
Name of publisher, distributor, etc. Mona Shafik Mahmoud Elashry ,
Date of publication, distribution, etc. 2017
300 ## - PHYSICAL DESCRIPTION
Extent 198 P. :
Other physical details charts , facsimiles ;
Dimensions 25cm
502 ## - DISSERTATION NOTE
Dissertation note Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology
520 ## - SUMMARY, ETC.
Summary, etc. Aim: The aim of this work is to investigate the expression pattern of B-cellspecifics moloney murine Leukemia virus integration site-1 (BMI-1) and brain and acute leukemia, cytoplasmic (BAALC) genes, their prognostic significance and their clinical significance in newly diagnosed Egyptian adult acute myeloid leukemia patients. Patients and Methods: The current study was carried out on 95 newly diagnosed adult (>18) acute myeloid leukemia patients, along with 20 age and sex matched apparently healthy normal controls. BMI-1 and BAALC expression was detected in the bone marrow of both patients and controls using quantitative real-time reverse transcription polymerase chain reaction (RT-PCR) with cut off value set at 50th percentile for both genes. Results: BMI-1 and BAALC expression was detected in 50% of cases but not in any controls. A statistical significant correlation was found between low BMI-1 expressers and hepatomegaly (p-value=0.007) while high BMI-1 expressers tend to have a lower hemoglobin level (<8) (p-value=0.081) and were more likely to be in the favorable cytogenetic risk group (P-value= 0.036). There was a statistically significant correlation between BAALC and age (P-value=0.015). The increase in BAALC expression was significantly associated with lymphadenopathy (p-value=0.043) and CD34 positive cases (p- value= 0.003). In addition, there was a trend of high BAALC expression to be associated with the more immature FAB subtypes (M1/M2) compared to the monocytic differentiated FAB (M4 and M5) (p-value {u2264}0.054). No statistical significance was noted for sex, splenomegaly, other hematological findings and response to treatment except for BAALC gene and response to treatment with a trend of higher death rate among low BAALC expressers and a higher incidence of CR among high BAALC expressers (P-value {u2264} 0.014). No statistical significance in overall survival and disease free survival for both genes was found
530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE
Additional physical form available note Issued also as CD
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Acute myeloid leukemia
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term AML
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term BMI-1
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Naglaa Mostafa Hassan ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Nevine Fawzy Shafik ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Ragia Hussein Badawy ,
Relator term
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a>
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Nazla
Reviser Revisor
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Shimaa
Reviser Cataloger
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Thesis
Holdings
Source of classification or shelving scheme Not for loan Home library Current library Date acquired Full call number Barcode Date last seen Koha item type Copy number
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة قاعة الرسائل الجامعية - الدور الاول 11.02.2024 Cai01.19.03.Ph.D.2017.Mo.P 01010110075515000 22.09.2023 Thesis  
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة مخـــزن الرســائل الجـــامعية - البدروم 11.02.2024 Cai01.19.03.Ph.D.2017.Mo.P 01020110075515000 22.09.2023 CD - Rom 75515.CD