MicroRNAs as a potential diagnostic new biomarkers in diagnosis of sepsis in pediatric patients / (Record no. 67204)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03119cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032036.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180830s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.28.Ph.D.2017.Ka.M |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Kariman Hassan Elhamamsy |
| 245 10 - TITLE STATEMENT | |
| Title | MicroRNAs as a potential diagnostic new biomarkers in diagnosis of sepsis in pediatric patients / |
| Statement of responsibility, etc. | Kariman Hassan Elhamamsy ; Supervised Iman Ahmed Ehsan Abdelmeguid , Lobna Mohamed Anas Fawaz , Olfat Gamil Shaker |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | كعلامات بيولوجية تشخيصية جديدة فى تشخيص تسمم الدم فى مرضى الأطفال microRNAs استخدام ال |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Kariman Hassan Elhamamsy , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 180 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Sepsis represents the main cause of mortality at intensive care units. The mortality rate for all septic episodes is 30{u2013}50%. miRNAs profile data could be beneficial as a specific diagnostic biomarker for the diagnosis of sepsis and systemic inflammatory response syndrome. The aim of this study was to access the role of certain miRNAs (miRNA-122, miRNA-181b, miRNA-223 and miRNA-146a) in diagnosis of sepsis and assess the probability of these miRNAs in prediction of poor prognosis and mortality. This could provide a potentially novel biomarker for sepsis detection and therapeutic strategies. Patients and methods: This was a prospective case control study of patients admitted to Cairo university pediatric intensive care unit (PICU). Forty cases (age: 1-24 months), 60% males and 40% females were compared to 40 healthy controls that were matched for age and sex. In addition to routine laboratory tests, cultures from different sites and imaging were done according to their need, special blood samples were collected for determination of miRNA by quantitative real time PCR technique. Results: miRNA-122 (19.5 ±29.8) and miRNA-181b (3.5 ±1.69) were found to be very sensitive and specific in diagnosing sepsis by their up-regulation early during septic conditions (p<0.001). While miRNA-223 (0.55 ±0.28) and miRNA-146a (0.15 ±0.10) are also very specific and highly sensitive in diagnosing sepsis conditions but by their down-regulation (p<0.001). We also found that only serum level of miRNA-223 can be used for poor prognosis prediction in sepsis with sensitivity=70% and specificity=75%, while the other three miRNAs could not predict poor prognosis during sepsis |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MicroRNA (miRNA) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pediatric intensive care unite |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Sepsis |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Iman Ahmed Ehsan Abdelmeguid , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lobna Mohamed Anas Fawaz , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Olfat Gamil Shaker , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.28.Ph.D.2017.Ka.M | 01010110075622000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.28.Ph.D.2017.Ka.M | 01020110075622000 | 22.09.2023 | CD - Rom | 75622.CD |