Anti-oxidant effect of purslane on cyclosporine (A)-induced submandibular salivary gland alterations in albino rats : (Record no. 67247)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03907cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032037.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180902s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.09.12.M.Sc.2017.He.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Heba Mahmoud Abdelwahab |
| 245 10 - TITLE STATEMENT | |
| Title | Anti-oxidant effect of purslane on cyclosporine (A)-induced submandibular salivary gland alterations in albino rats : |
| Remainder of title | Animal study / |
| Statement of responsibility, etc. | Heba Mahmoud Abdelwahab ; Supervised Rabab Tawfik Mubarak , Iman Mahmoud Aboushady |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الدور المضاد للأكسدة للرّجلة علي تغيّرات الغدد اللعابية تحت الفكية المسبّبة بالسايكلوسبورين (أ) في الجرذان البيضاء : |
| Remainder of title | دراسة في الحيوانات |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Heba Mahmoud Abdelwahab , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 95 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral Biology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Salivary glands are exocrine glands constituting part of the digestive system. They are affected by various drugs, among which, are the immunosuppressive drugs, like Cyclosporine-A (CsA) which plays a major role in transplant medicine. Thus, this work aimed to study the effects of CsA on the rat submandibular salivary glands and to evaluate the possible therapeutic effect of purslane on CsA induced salivary gland alterations. Materials & Methods: 30 adult male albino rats, about 3-4 months age and 150-200 gm weight, were equally divided into 3 groups: control group which received a vehicle, CsA group which received 20 mg/kg/day of CsA, and combination group which received CsA combined to 400mg/kg/day of purslane extract. All rats were sacrificed 3 weeks from the beginning of the experiment then the submandibular salivary glands were dissected out, fixed, embedded and tissue sections were prepared for histological staining by hematoxylin and eosin (H&E) as well as immunohistochemical staining through anti-Ki67 antibody. Finally, the area percentage of Ki-67 immunoexpression was measured and statistically compared among the studied groups. Results: histological examination of the control group revealed the normal histology of the submandibular salivary gland, while in the CsA group; the acinar cells showed numerous vacuolizations and reduced cytoplasmic basophilia. The granular convoluted tubules (GCTs) revealed decreased apical eosinophilic granular content & cells of the duct system presented vacuolizations. Some excretory ducts retained secretion and marked chronic inflammatory cells infiltrate as well as congested blood vessels were seen. Regarding the combination group, the acini had well defined boundaries and marked reduction occurred in the number of vacuolizations among the acinar and ductal cells. The acini revealed increased cytoplasmic basophilia and the GCTs displayed increased granular eosinophilic content. Excretory ducts rarely retained secretion, some blood vessels were congested and the C.T. septa scarcely displayed chronic inflammatory cell infiltration. Immunohistochemical examination of the Ki-67 stained sections showed a few number of positive nuclei in the control group, while the CsA group revealed an apparent increase in the number of positive nuclei. On the other hand, the combination group displayed marked reduction in Ki-67 immunoreactivity than that in the CsA group |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cyclosporine-A |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Purslane |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Submandibular salivary glands |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Iman Mahmoud Aboushady , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tawfik Mubarak , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.09.12.M.Sc.2017.He.A | 01010110075641000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.09.12.M.Sc.2017.He.A | 01020110075641000 | 22.09.2023 | CD - Rom | 75641.CD |