Effect of mangiferin on multiple organ dysfunction syndrome induced by intestinal ischemia/reperfusion in rats / (Record no. 67281)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03247cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032038.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180903s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2018.Sh.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Shorouk Mohamed Mostafa Ibrahim Elsayyad |
| 245 10 - TITLE STATEMENT | |
| Title | Effect of mangiferin on multiple organ dysfunction syndrome induced by intestinal ischemia/reperfusion in rats / |
| Statement of responsibility, etc. | Shorouk Mohamed Mostafa Ibrahim Elsayyad ; Supervised Hanan Salah Eldin Elabhar , Azza Sayed M. Awad , |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تأثير المانجفيرين في متلازمة قصور وظائف الأعضاء المتعددة المحدثة بسبب حبس وإعادة التروية الدموية في الأمعاء الدقيقة في الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Shorouk Mohamed Mostafa Ibrahim Elsayyad , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 227 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim:Mangiferin (MF), a xanthonoid from Mangiferaindica, possesses anti-inflammatory, immunomodulatory, and potent antioxidant effects; however, its protective effect against multiple organ dysfunction syndrome has not been fully clarified. The study was designed to assess the possible mechanism of action of MF20 and its nano-formulation (NMF10) against mesenteric I/R model. MainMethods:Male Wister rats were randomly allocated into 6 groups (n= 6); in the first group, rats received saline and the SMA was manipulated only to serve as the sham-operated group. In the 5 other groups rats were subjected to I/R, which was induced by clamping the superior mesenteric artery for 30 minutes followed by declamping for 60 minutes. Group 2 was donated as the untreated I/R control and animals received saline only, while in groups 3 and 4, animals were pre-treated with MF (20 mg/kg, i.p) or NMF (10mg/kg, i.p), for 3 days before I/R, while rats in groups 5 and 6 received the two blockers; viz.,methyllycaconitine (MLA) and atropine (Sigma-Aldrich Chemical Company, MO, USA) 30 min before NMF10for 3 days. MF20 was dissolved in the vehicle (2% DMSO in saline), while NMF10 were sonicated well before administration. Atropine and methyllycaconitine (MLA) were diluted with 0.9% saline prior to the experiment. Key findings: The mechanistic studies revealed that MF20 protected the 3 organs studied, viz., liver, kidney and intestine partly via increasing the content of Ý-catenin and PPAR-Þ along with decreasing that of GSK-3Ý and the phosphorylated NF-{u049B}B-p65. MF20 and NMF10 antioxidant effect was evidenced by increasing contents of total antioxidant capacity and GST, besides normalizing that of MDA and increasing m-RNA levels of NRF-2 and HO-1 |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Intestinal ischemia/reperfusion |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Mangiferin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | PPAR-Þ |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Azza Sayed M. Awad , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Salah Eldin Elabhar, |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2018.Sh.E | 01010110075656000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2018.Sh.E | 01020110075656000 | 22.09.2023 | CD - Rom | 75656.CD |