MicroRNAs as candidate biomarkers in systemic lupus erythematosus patients / (Record no. 67397)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03378cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032041.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180910s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.Ph.D.2018.Di.M |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Diana Nagy Garas Masoud |
| 245 10 - TITLE STATEMENT | |
| Title | MicroRNAs as candidate biomarkers in systemic lupus erythematosus patients / |
| Statement of responsibility, etc. | Diana Nagy Garas Masoud ; Supervised Taghrid Mohamed Gaafar , Noha Mohamed Hosni Shaheen , Hala Ahmed Raafat |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | أحماض الريبونيوكلييك الدقيقة كمؤشرات حيوية في مرضى الذئبة الحمراء |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Diana Nagy Garas Masoud , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 199 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease that can affect the major»ity of organs and tissues.The clinical presentations of SLE can range from mild to severe and the course is unpredictable, with periods of remission and flares. Lupus nephritis is a severe consequence of SLE and an important driver of morbidity and mortality in SLEMicroRNAs (miRNAs) are a class of small (~22nucleotides) noncoding RNAs that modulate gene expression and regulate various cellular processes and are critically involved in many physiologic and pathologic processes in health and disease including immune system disease. Aim of work The aim of the study is to identify the use of microRNA-126 and microRNA-146a as candidate diagnostic and prognostic biomarkers and their correlation with disease activity in SLE patients Subjects and methods Our study included 74 SLE patients (66 females and 8 males) with ages ranging from 13 years to 57 years. Patients with SLE fulfilled the American College of Rheumatology classification criteria for SLE. Besides, our study included 40 age and sex matched healthy controls, for comparison. Determination of plasma levels of miR-146a and miR-126 were done using taqman quantitative Real time-PCR using RNU6B as internal controls.Measurement of serum interferon alpha (IFN-Ü) by ELISA technique was performed from SLE patients and healthy controls.Data was correlated with disease activity and hence evaluation of their prognosis. Results: The median value of fold change of plasma miR-146a levels showed a significant statistical decrease in SLE and lupus nephritis patients compared to the healthy control group and there was also a decrease in plasma levels of miR-146a in active SLE patients versus the inactive group and healthy control group. However, there was no statistical significant difference in plasma miR-126 levels and serum IFN-Ü in SLE and lupus nephritis patients compared to the healthy control group |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Lupus nephritis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MiR-146a |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Systemic lupus erythematosus (SLE) |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Ahmed Raafat , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Noha Mohamed Hosni Shaheen , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Taghrid Mohamed Gaafar , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.Ph.D.2018.Di.M | 01010110075714000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.Ph.D.2018.Di.M | 01020110075714000 | 22.09.2023 | CD - Rom | 75714.CD |