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MicroRNAs as candidate biomarkers in systemic lupus erythematosus patients / (Record no. 67397)

MARC details
000 -LEADER
fixed length control field 03378cam a2200349 a 4500
003 - CONTROL NUMBER IDENTIFIER
control field EG-GiCUC
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250223032041.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 180910s2018 ua dh f m 000 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency EG-GiCUC
Language of cataloging eng
Transcribing agency EG-GiCUC
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title eng
049 ## - LOCAL HOLDINGS (OCLC)
Holding library Deposite
097 ## - Thesis Degree
Thesis Level Ph.D
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
Classification number Cai01.11.07.Ph.D.2018.Di.M
100 0# - MAIN ENTRY--PERSONAL NAME
Personal name Diana Nagy Garas Masoud
245 10 - TITLE STATEMENT
Title MicroRNAs as candidate biomarkers in systemic lupus erythematosus patients /
Statement of responsibility, etc. Diana Nagy Garas Masoud ; Supervised Taghrid Mohamed Gaafar , Noha Mohamed Hosni Shaheen , Hala Ahmed Raafat
246 15 - VARYING FORM OF TITLE
Title proper/short title أحماض الريبونيوكلييك الدقيقة كمؤشرات حيوية في مرضى الذئبة الحمراء
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Cairo :
Name of publisher, distributor, etc. Diana Nagy Garas Masoud ,
Date of publication, distribution, etc. 2018
300 ## - PHYSICAL DESCRIPTION
Extent 199 P. :
Other physical details charts , facsimiles ;
Dimensions 25cm
502 ## - DISSERTATION NOTE
Dissertation note Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
520 ## - SUMMARY, ETC.
Summary, etc. Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease that can affect the major»ity of organs and tissues.The clinical presentations of SLE can range from mild to severe and the course is unpredictable, with periods of remission and flares. Lupus nephritis is a severe consequence of SLE and an important driver of morbidity and mortality in SLEMicroRNAs (miRNAs) are a class of small (~22nucleotides) noncoding RNAs that modulate gene expression and regulate various cellular processes and are critically involved in many physiologic and pathologic processes in health and disease including immune system disease. Aim of work The aim of the study is to identify the use of microRNA-126 and microRNA-146a as candidate diagnostic and prognostic biomarkers and their correlation with disease activity in SLE patients Subjects and methods Our study included 74 SLE patients (66 females and 8 males) with ages ranging from 13 years to 57 years. Patients with SLE fulfilled the American College of Rheumatology classification criteria for SLE. Besides, our study included 40 age and sex matched healthy controls, for comparison. Determination of plasma levels of miR-146a and miR-126 were done using taqman quantitative Real time-PCR using RNU6B as internal controls.Measurement of serum interferon alpha (IFN-Ü) by ELISA technique was performed from SLE patients and healthy controls.Data was correlated with disease activity and hence evaluation of their prognosis. Results: The median value of fold change of plasma miR-146a levels showed a significant statistical decrease in SLE and lupus nephritis patients compared to the healthy control group and there was also a decrease in plasma levels of miR-146a in active SLE patients versus the inactive group and healthy control group. However, there was no statistical significant difference in plasma miR-126 levels and serum IFN-Ü in SLE and lupus nephritis patients compared to the healthy control group
530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE
Additional physical form available note Issued also as CD
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Lupus nephritis
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term MiR-146a
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Systemic lupus erythematosus (SLE)
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Hala Ahmed Raafat ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Noha Mohamed Hosni Shaheen ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Taghrid Mohamed Gaafar ,
Relator term
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a>
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Nazla
Reviser Revisor
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Shimaa
Reviser Cataloger
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Thesis
Holdings
Source of classification or shelving scheme Not for loan Home library Current library Date acquired Full call number Barcode Date last seen Koha item type Copy number
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة قاعة الرسائل الجامعية - الدور الاول 11.02.2024 Cai01.11.07.Ph.D.2018.Di.M 01010110075714000 22.09.2023 Thesis  
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة مخـــزن الرســائل الجـــامعية - البدروم 11.02.2024 Cai01.11.07.Ph.D.2018.Di.M 01020110075714000 22.09.2023 CD - Rom 75714.CD