Interleukin-10 gene polymorphism in Egyptian breast cancer patients / (Record no. 67431)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03376cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032042.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180912s2017 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.21.M.Sc.2017.Sh.I |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Shrouk Khalaf Elsayed Ahmed Ali |
| 245 10 - TITLE STATEMENT | |
| Title | Interleukin-10 gene polymorphism in Egyptian breast cancer patients / |
| Statement of responsibility, etc. | Shrouk Khalaf Elsayed Ahmed Ali ; Supervised Mona Mostafa Mohamed , Salwa Farouk Sabet , Mohamed Elsayed Elshinawi |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التنميط الجيني للانترلوكين 10 في مرضى سرطان الثدي المصريين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Shrouk Khalaf Elsayed Ahmed Ali , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 108 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Breast cancer isthe main cause of death in women worldwide. Indeed, genetic variation plays a vital role in carcinogenesis. Inflammatory breast cancer (IBC) is an aggressive and fatal form of breast cancer that is more prominent among young women and is characterized by a high number of axillary lymph node metastases at the time of presentation, poor prognosis and low survival rate(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014)(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014)(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014)(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014)(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014). Interleukin-10 is involved in carcinogenesis by supporting tumor escape from the immune response. The aim of this study was to assess the single nucleotide polymorphisms, -1082A/G, -819T/C and -592A/C, in interleukin-10 gene promoter in inflammatory breast cancer compared to non-inflammatory breast cancer and association of these polymorphisms with interleukin-10 gene expression. As we targeted the most commonly three studied IL-10 promoter SNPs; rs1800896 ({u2212}1082A/G), rs1800871 ({u2212}819T/ C) and rs1800872 ({u2212}592A/C), GCC haplotype was found in association with over-increase in the risk of IBC. Also we found no association of IL-10 gene promoter polymorphisms in breast cancer progression (Stage, Grade, lymph node metastasis and distant metastasis). Moreover, we found increased expression of IL-10 gene in non-IBC and IBC than healthy control samples but a higher significant expression of IL-10 mRNA in IBC carcinoma tissues compared to non-IBC. GCC haplotype was the most correlated with increased expression of IL-10 than other estimated haplotype, and a markedly significant increase in IL-10 expression of GCC haplotype in IBC than non-IBC carcinoma tissue |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Haplotype |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Inflammatory breast cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Interleukin-10 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Elsayed Elshinawi , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mona Mostafa Mohamed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Salwa Farouk Sabet , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.21.M.Sc.2017.Sh.I | 01010110075743000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.21.M.Sc.2017.Sh.I | 01020110075743000 | 22.09.2023 | CD - Rom | 75743.CD |