A Study on the potential in vitro antimycobacterial activity of natural product(s) from selected wild plants / (Record no. 67512)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02616cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180918s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.06.Ph.D.2018.Ne.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nesreen Ahmed Safwat |
| 245 12 - TITLE STATEMENT | |
| Title | A Study on the potential in vitro antimycobacterial activity of natural product(s) from selected wild plants / |
| Statement of responsibility, etc. | Nesreen Ahmed Safwat ; Supervised Mohammed A. Ramadan , Ramy K. Aziz , Khadegah F. Amer |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة علي الفاعلية المعملية المحتملة المضادة للميكوباكتيريام لمنتجات طبيعية المستخرجة من نباتات برية مختارة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nesreen Ahmed Safwat , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 156 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Tuberculosis remains a major health problem accentuated by the rise of resistance to all available drugs. Therefore, this study was launched to discover novel antituberculosis agents from natural products.Twelve wild plants were in vitro screened for their activity against typical and atypical Mycobacterium species. The most active plant, Euphorbia paralias, was further fractionated with different organic solvents, and the activity of the obtained fractions was determined by agar diffusion and broth microdilution methods.The methanol fraction was found to be the most active against Mycobacterium spp.,and was non-toxic in doses up to 10 g/kg of animal weight. The main component was separated by column chromatography then identified by ultraviolet spectroscopy and nuclear magnetic resonance analysis as quercetin-3-O-Ý-D-glucoside. Treatment with quercetin-3-O-Ý-D-glucoside inhibited cell survival of HepG2 and A549 cells in a dose and time dependent manner. Molecular docking analysis suggested that quercetin-3-O-Ý-D-glucoside inhibits the glutamine synthetase enzyme, a promising target for the development of drugs for tuberculosis therapy. This current study prediction was confirmed by the in vitro glutamine synthetase biosynthesis assay |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Euphorbia paralias |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Mycobacterium |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Tuberculosis |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Khadegah F. Amer , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohammed A. Ramadan , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ramy K. Aziz , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.06.Ph.D.2018.Ne.S | 01010110075765000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.06.Ph.D.2018.Ne.S | 01020110075765000 | 22.09.2023 | CD - Rom | 75765.CD |