A comparative histological study on the effect of adipose-derived stem cells versus their conditioned medium on indomethacin induced enteritis in adult female albino rats / (Record no. 67518)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03700cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032045.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180918s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.16.Ph.D.2018.As.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Asmaa Mohamed Abdelhameed |
| 245 12 - TITLE STATEMENT | |
| Title | A comparative histological study on the effect of adipose-derived stem cells versus their conditioned medium on indomethacin induced enteritis in adult female albino rats / |
| Statement of responsibility, etc. | Asmaa Mohamed Abdelhameed ; Supervised Abeer Fouad Abdelmohsen , Nagla Mohamed Salama , Laila Ahmed Rashed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة هستولوجية مقارنة علي تأثير الخلايا الجذعية المستخلصه من النسيج الدهني مقابل الوسط المكيف لها في التهاب الأمعاء الدقيقه المستحث تجريبيا بالإندوميثاسين في إناث الجرذان البيضاء البالغه |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Asmaa Mohamed Abdelhameed , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 200 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Histology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background and Aim of the work: Inflammatory bowel disease, including Crohn{u2019}s disease (CD), is a chronic complex immune-inflammatory disorder with increasing prevalence and inadequate conventional treatment. So, this work was conducted to evaluate the therapeutic effect of adipose-derived mesenchymal stem cells (ADSCs) versus ADSC-conditioned medium (CM) in a rat model of enteritis (Crohn{u2019}s disease). Materials and Methods: Fifty-six female albino rats were used in this study, 16 rats served as control (group I). In the remaining 40 rats, enteritis was induced by SC injection of 2 doses of indomethacin 7.5 mg/kg, on days 0 &1 of the experiment.They were left until day 10 then divided equally into 5 groups: Groups II & III received no further treatment and sacrificed at days 10 and 24 respectively. Groups IV,V &VI were treated with ADSCs (1{u00D7}106 cells, IV single dose ), ADSC-CM (0.5ml IP, 5 doses) and DMEM (0.5ml IP, 5 doses) respectively; they were all sacrificed at day 24. Ileum specimens were taken from all animals and stained with H&E, Masson's trichrome & Alcian blue/ PAS stains as well as MMP1 and PCNA immunostains. Morphometric measurements of area % of collagen & MMP1, number of goblet cells & PCNA positive cells as well as optical density of Alcian blue/ PAS reaction were taken and statistically analyzed.Results: Groups II, III and VI revealed obvious damage of villi and crypts, desquamation of epithelium, oedema and obvious mononuclear cellular infiltration together with significant decrease in number of goblet cells & PCNA +ve cells as well as in the optical density of Alcian blue/ PAS reaction and significant increase in the area % of collagen (only in groups III&VI) and MMP1 as compared to control. Groups IV and V nearly regained the normal histological structure of villi & crypts with significant increase in number of goblet cells & PCNA +ve cells as well as in the optical density of Alcian blue/ PAS reaction and significant decrease in the area % of collagen and MMP1 |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Crohn{u2019}s disease |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Enteritis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Indomethacin |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abeer Fouad Abdelmohsen , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Laila Ahmed Rashed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nagla Mohamed Salama , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.16.Ph.D.2018.As.C | 01010110075839000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.16.Ph.D.2018.As.C | 01020110075839000 | 22.09.2023 | CD - Rom | 75839.CD |