MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03002cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
180918s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.18.Ph.D.2018.Ib.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ibrahim Ahmed Ibrahim Abdalgawad |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Significance of serum microrna-122 levels in non-alcoholic fatty liver disease among Egyptian patients / |
| Statement of responsibility, etc. |
Ibrahim Ahmed Ibrahim Abdalgawad ; Supervised Mona Mohamed Ahmed Thabet , Soheir Abdelfattah Abuelfadl , Laila Ahmed Rashed |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
أهمية مستوي الحامض النووى الريبوزى الصغرى رقم 122 فى مصل الدم فى مرض تدهن الكبد الغير كحولى بين المرضى المصريين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Ibrahim Ahmed Ibrahim Abdalgawad , |
| Date of publication, distribution, etc. |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
150 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Internal Medicine |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Background: Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent condition. MicroRNA-122 (miRNA-122) is the most abundant micro-RNA (miRNA) in the liver, and it regulates metabolic pathways, including cholesterol biosynthesis, fatty acid synthesis and oxidation. Aim of the work: In the present study we aim to examine the correlation between the serum miRNA-122 expression levels and the presence of NAFLD and to analyze the relationship between the expressions of the serum miRNA-122 and different grades of (steatosis and fibrosis) using (ultra sonography and fibroscan) in NAFLD patients.Subjects and methods: patients were divided according to ultrasonographic findings into three groups with different degrees of steatosis (40 mild, 40 moderate and 40 patients with severe steatosis) in addition to 60 Egyptian age and sex matched controls. All patients enrolled in the study were subjected to full history taking, thorough examination, laboratory investigations (serum miRNA-122 levels by real-time polymerase chain reaction (PCR), insulin, lipid profile, blood glucose, AST, ALT) and radiological investigation in the form of abdominal ultra sonography and fibroscan. Results: This study found a statistical significant increase in serum miRNA-122 levels in NAFLD patients with compared to controls, with lower levels in patients with mild steatosis than those with moderate and severe steatosis. Also miRNA-122 levels were inversely correlated with fibrosis degree. Also in this study serum miRNA-122 levels were strongly associated with liver enzymes (ALT, AST and GGT) |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
MicroRNA-122 |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
NAFLD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Ultra sonography |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Laila Ahmed Rashed , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed Ahmed Thabet , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Soheir Abdelfattah Abuelfadl , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
