The effect of mesenchymal stem cells derived microvesicles on the treatment of experimental CCL₄ induced liver fibrosis in rats / (Record no. 67588)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03097cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032047.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180922s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.03.M.Sc.2018.Ma.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Manar Monir Youssef Amin |
| 245 14 - TITLE STATEMENT | |
| Title | The effect of mesenchymal stem cells derived microvesicles on the treatment of experimental CCL₄ induced liver fibrosis in rats / |
| Statement of responsibility, etc. | Manar Monir Youssef Amin ; Supervised Dina Sabry Abdelfatah , Abbas Mohamed Abbas , Heba Abdelmonem Ibrahim |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تأثير الحويصلات الدقيقة المستخلصة من الخلايا الجذعية الميشنزمية على علاج التليف الكبدى الناجم عن حقن رباعى كلوريد الكربون فى فئران التجارب |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Manar Monir Youssef Amin , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 118 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background &Aim:Stem cell-based therapies especially the mesenchymal stem cells (MSCs) have potential for treatment of liver injury by contributing to regenerative responses, through functional tissue replacement or paracrine effects. The release of microvesicles (MVs) from these cells has been implicated in intercellular communication, and may contribute to beneficial paracrine effects of stem cell-based therapies. The aim of our study is to investigate the effect of administration of murine bone marrowMSC-MVs(mBM-MSC-MVs) on the treatment of carbon tetrachloride (CCL₄) induced liver fibrosis in rats.Thereby, to determine their potential utility as therapeutic agents for tissue repair and functional restoration in liver fibrosis. Methods : Our work included: Preparation, isolation then identification of BM-MSCs in culture by morphology and flow cytometry, preparation then identification of BM-MSC-MVs by transmission electron microscopy and polymerase chain reaction (PCR) detection of Ý-integrin gene expression, then preparation of rat model of liver fibrosis by CCl4-induced injury, injection of prepared BM-MSC-MVs in injured rats then the effects of BM-MSC-MVs were evaluated by biochemical analysis of liver functions, RNA gene expression quantitation for collagen-1Ü, transforming growth factor Ý(TGF-Ý), interleukin-1Ý(IL-1Ý), vascular endothelial growth factor (VEGF) by real time reverse transcription PCR (RT-PCR) techniquesand finally histopathologicalanalysis of the liver tissues of all studied groups |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Liver fibrosis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Mesenchymal stem cells |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Microvesicles |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abbas Mohamed Abbas , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dina Sabry Abdelfatah , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heba Abdelmonem Ibrahim , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.03.M.Sc.2018.Ma.E | 01010110075877000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.03.M.Sc.2018.Ma.E | 01020110075877000 | 22.09.2023 | CD - Rom | 75877.CD |