Serum YKL-40 levels in patients with B-thalassemia: relation to viral hepatitis, liver stiffness and hepatic iron concentration / (Record no. 67656)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03089cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032049.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180926s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.28.Ph.D.2018.Sa.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Samah Ahmed Mostafa |
| 245 10 - TITLE STATEMENT | |
| Title | Serum YKL-40 levels in patients with B-thalassemia: relation to viral hepatitis, liver stiffness and hepatic iron concentration / |
| Statement of responsibility, etc. | Samah Ahmed Mostafa ; Supervised Mona Mohamed Hamdy , Amina Abdelsalam Mahmoud , Hadeel Mohamed Seif Eldin |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | مستوى واى كى ال 40 فى الدم فى مرضى انيميا البحر المتوسط و علاقته بالتهاب الكبد الفيروسى و تليف الكبد و تركيز الحديد بالكبد |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Samah Ahmed Mostafa , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 166 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: To evaluate serum YKL-40 thalassemia and its relation to viral hepatitis, liver stiffness as assessed by transient elastography (FibroScan, FS) and Hepatic Iron concentration. Methods: A cross sectional study included 100 patients-TM (43 males and 57 females) with mean age 13.8±2.7 years (range: 5-18 years). Serum ferritin level, Liver enzymes (ALT and AST), HBs Ag, Anti HCV Ab and Serum YKL-40 using ELISA kit were evaluated. All patients were subjected to Liver MRI T2* to detect liver iron content by the sequence and Transient elastography (FibroScan, FS) to assess degree of liver stiffness. Results: Mean fibroscan value was (10.9±11.5) kPa with a median 6.7 (range 1.3 to 47) kPa. 64 (64%) patients were categorized as F0-1 and 17 (17%) were stage F2-3, 19 (19%) patients had severe fibrosis. Their median serum ferritin was 3100 ng\ml, with 61 (61%) patients had values exceeding 2500æg/L. Median cardiac T2* was 24.2 with 30 patients had values below 20 ms, and the median LIC was 16.21 mg/g DW with 68 patients showed readings above 7 mg/g dw. YKL-40 was evaluated as a marker of inflammation and liver fibrosis and showed mean value 1505.1 (±960.9) pg/ml, and range from 500 to 3529 pg/ml. Mean YKL-40 was significantly higher among males (p=0.03), abnormal liver enzymes, splenectomised patients, patients with HBV sero-positivity, those with moderate elevation of T2* and patients with high grades of liver fibrosis (p<0.05). YKL-40 showed positive correlation with the rate of transfusion, LIC, ferritin, ALT and AST but negative correlation with weight, height and T2* |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Serum YKL-40 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Thalassemia major |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Viral hepatitis |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amina Abdelsalam Mahmoud , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hadeel Mohamed Seif Eldin , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mona Mohamed Hamdy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.28.Ph.D.2018.Sa.S | 01010110075904000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.28.Ph.D.2018.Sa.S | 01020110075904000 | 22.09.2023 | CD - Rom | 75904.CD |