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Serum diagnostic markers for hepatocellular carcinoma associated with HCV infection / (Record no. 67735)

MARC details
000 -LEADER
fixed length control field 03122cam a2200349 a 4500
003 - CONTROL NUMBER IDENTIFIER
control field EG-GiCUC
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250223032052.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 180930s2017 ua dh f m 000 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency EG-GiCUC
Language of cataloging eng
Transcribing agency EG-GiCUC
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title eng
049 ## - LOCAL HOLDINGS (OCLC)
Holding library Deposite
097 ## - Thesis Degree
Thesis Level M.Sc
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
Classification number Cai01.12.02.M.Sc.2017.Er.S
100 0# - MAIN ENTRY--PERSONAL NAME
Personal name Erin Awad Rezk Sharkawy
245 10 - TITLE STATEMENT
Title Serum diagnostic markers for hepatocellular carcinoma associated with HCV infection /
Statement of responsibility, etc. Erin Awad Rezk Sharkawy ; Supervised Mohamed Ali Eldesouqi , Abdelhady A. Abdelwahab , Mohamed A. Ezzel Arab
246 15 - VARYING FORM OF TITLE
Title proper/short title دلالات تشخيصية لسرطان الكبد في مصل دم المصابين بفيروس الكبد الوبائي سي
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Cairo :
Name of publisher, distributor, etc. Erin Awad Rezk Sharkawy ,
Date of publication, distribution, etc. 2017
300 ## - PHYSICAL DESCRIPTION
Extent 133 P. :
Other physical details charts , facsimiles ;
Dimensions 25cm
502 ## - DISSERTATION NOTE
Dissertation note Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry
520 ## - SUMMARY, ETC.
Summary, etc. Hepatitis C virus (HCV) is a single stranded RNA virus, Flaviviridae family. It is the main cause of chronic HCV diseases like Fibrosis, Cirrhosis, HCC and end stage liver disease. In Egypt, more that 94% of all HCC cases are associated with chronic HCV infection. Early diagnosis can significantly improve the low survival of HCC patients. However, current diagnostic markers are compromised and limited by their low sensitivity and specivicity. Our previous work refered to a group of protiens that are elevated in HCC and can be promising biomarkers for early detection. So our main aim is to validate whether four circulating proteins can be used as potential diagnostic biomarkers in Egyptian HCC patients infected with HCV virus. In this study, four proteins (SAA2, KNG1, PON1 and GAL3) in additional to AFP as a standard tumor marker were analyzed in 143 serum samples; 51 HCV associated HCC patients, 52 HCV pateints in addition to 40 healthy control subjects using sandwich ELISA technique.The sensitivity and specificity of those proteins were also assessed.Highly significant increase in the mean level of SAA2, KNG1 and GAL3 proteins was reported whereas a highly significant decrease in the level of PON1 protein was recorded compared to both HCV group and healthy contrls. In additon, the diangostic performance was determined by receiver operating characteristics (ROC) curve analysis. SAA2 provided the highest diagnostic accuracy (AUC=0.925) in HCC patients. Morever, the diagnostic accuracy increased slightly when SAA2 was combined with AFP (AUC=0.946).Conclusion: Serum SAA2 protein may have a diagnostic value with high accuracy for discriminating HCC associated with HCV patients from both controls and high-risk patients
530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE
Additional physical form available note Issued also as CD
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Hepatitis C virus
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Hepatocellular Carcinoma
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Serum Amyloid A2
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Abdelhady A. Abdelwahab ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Mohamed A. Ezzel Arab ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Mohamed Ali Eldesouqi ,
Relator term
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a>
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Nazla
Reviser Revisor
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Shimaa
Reviser Cataloger
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Thesis
Holdings
Source of classification or shelving scheme Not for loan Home library Current library Date acquired Full call number Barcode Date last seen Koha item type Copy number
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة قاعة الرسائل الجامعية - الدور الاول 11.02.2024 Cai01.12.02.M.Sc.2017.Er.S 01010110075964000 22.09.2023 Thesis  
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة مخـــزن الرســائل الجـــامعية - البدروم 11.02.2024 Cai01.12.02.M.Sc.2017.Er.S 01020110075964000 22.09.2023 CD - Rom 75964.CD