Serum diagnostic markers for hepatocellular carcinoma associated with HCV infection / (Record no. 67735)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03122cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032052.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180930s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.02.M.Sc.2017.Er.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Erin Awad Rezk Sharkawy |
| 245 10 - TITLE STATEMENT | |
| Title | Serum diagnostic markers for hepatocellular carcinoma associated with HCV infection / |
| Statement of responsibility, etc. | Erin Awad Rezk Sharkawy ; Supervised Mohamed Ali Eldesouqi , Abdelhady A. Abdelwahab , Mohamed A. Ezzel Arab |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دلالات تشخيصية لسرطان الكبد في مصل دم المصابين بفيروس الكبد الوبائي سي |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Erin Awad Rezk Sharkawy , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 133 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Hepatitis C virus (HCV) is a single stranded RNA virus, Flaviviridae family. It is the main cause of chronic HCV diseases like Fibrosis, Cirrhosis, HCC and end stage liver disease. In Egypt, more that 94% of all HCC cases are associated with chronic HCV infection. Early diagnosis can significantly improve the low survival of HCC patients. However, current diagnostic markers are compromised and limited by their low sensitivity and specivicity. Our previous work refered to a group of protiens that are elevated in HCC and can be promising biomarkers for early detection. So our main aim is to validate whether four circulating proteins can be used as potential diagnostic biomarkers in Egyptian HCC patients infected with HCV virus. In this study, four proteins (SAA2, KNG1, PON1 and GAL3) in additional to AFP as a standard tumor marker were analyzed in 143 serum samples; 51 HCV associated HCC patients, 52 HCV pateints in addition to 40 healthy control subjects using sandwich ELISA technique.The sensitivity and specificity of those proteins were also assessed.Highly significant increase in the mean level of SAA2, KNG1 and GAL3 proteins was reported whereas a highly significant decrease in the level of PON1 protein was recorded compared to both HCV group and healthy contrls. In additon, the diangostic performance was determined by receiver operating characteristics (ROC) curve analysis. SAA2 provided the highest diagnostic accuracy (AUC=0.925) in HCC patients. Morever, the diagnostic accuracy increased slightly when SAA2 was combined with AFP (AUC=0.946).Conclusion: Serum SAA2 protein may have a diagnostic value with high accuracy for discriminating HCC associated with HCV patients from both controls and high-risk patients |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatitis C virus |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatocellular Carcinoma |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Serum Amyloid A2 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abdelhady A. Abdelwahab , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed A. Ezzel Arab , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Ali Eldesouqi , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.02.M.Sc.2017.Er.S | 01010110075964000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.02.M.Sc.2017.Er.S | 01020110075964000 | 22.09.2023 | CD - Rom | 75964.CD |