Targeting hepatic stellate cells using valsartan and imatinib nanomedicine in experimentally induced liver fibrosis in rats / (Record no. 67742)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03257cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032052.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180930s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2018.Ne.T |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nesrine Saeid Ibrahim Abdelquader Elmezayen |
| 245 10 - TITLE STATEMENT | |
| Title | Targeting hepatic stellate cells using valsartan and imatinib nanomedicine in experimentally induced liver fibrosis in rats / |
| Statement of responsibility, etc. | Nesrine Saeid Ibrahim Abdelquader Elmezayen ; Supervised Aiman S. Elkhatib , Mahmoud M. Khattab , Thanaa I. Shalaby |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | استهداف الخلايا النجمية الكبدية باستخدام تقنية النانو لدوائي الفالسارتان وايماتينيب في تليف الكبد المستحدث تجريبيا في الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nesrine Saeid Ibrahim Abdelquader Elmezayen , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 234 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Liver fibrosis is a serious health problem as an intermediate stage in the sequential progression of all chronic liver diseases to cirrhosis then to hepatocellular carcinoma. Despite the growing eagerness to develop anti-fibrotic therapies following deliberating that hepatic fibrosis has tendency to regress, none of the tested anti-fibrotic therapies was approved so far. Hepatic stellate cells (HSCs) are the sole hepatic vitamin A (VA) storage cells besides they are the main regulators for liver fibrosis pathogenesis. A consequence of chronic liver injury is the persistent HSCs activation and trans-differentiation into highly proliferative and matrix-producing myofibroblastes with subsequent loss of the VA storing capacity. These facts paved the way for the idea that HSCs actively-targeted therapy may provide a cure for this reversible morbid condition. The ideal candidate drug for HSCs targeting would be the one which have multiple points of therapeutic intervention, can be easily delivered and is well tolerated. Valsartan and imatinib may represent such candidates; valsartan is an inverse agonist to the over-expressed angiotensin II type1 receptor (AT1R) as well as a partial agonist to the depleted nuclear receptor; peroxisome proliferator-activated receptor gamma (PPAR-Þ) in activated HSCs.On the other hand, being a tyrosine kinase receptor inhibitor, imatinib inhibits platelet-derived growth factor receptor-beta (PDGFR-Ý) and c-Abl. Therefore it inhibits two key profibrotic pathways; PDGF-Ý and transforming growth factor-beta (TGF-Ý). However, efficacy of valsartan on AT1R and PPAR-Þ necessitates high drug permeability which is lacking in valsartan |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Liver fibrosis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Targeting hepatic stellate cells |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Valsartan |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Aiman S. Elkhatib , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mahmoud M. Khattab , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Thanaa I. Shalaby , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2018.Ne.T | 01010110075972000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2018.Ne.T | 01020110075972000 | 22.09.2023 | CD - Rom | 75972.CD |