Endophytic fungi isolated from catharanthus roseus as a source of antimicrobial and cytotoxic secondary metabolites / (Record no. 67892)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03179cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032057.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 181010s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.18.M.Sc.2018.He.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hedia Allah Ebrahim Eid |
| 245 10 - TITLE STATEMENT | |
| Title | Endophytic fungi isolated from catharanthus roseus as a source of antimicrobial and cytotoxic secondary metabolites / |
| Statement of responsibility, etc. | Hedia Allah Ebrahim Eid ; Supervised Tahany Mohamed A. Abdelrahman , Azza Hassan Morsi , Eman Abdullah Mohamed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الفطرياث الداخلية المعزولة من نبات الونكا كمصدر للمركبات الثانوية المضادة للميكروبات والسمية الخلوية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Hedia Allah Ebrahim Eid , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 108 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Microbiology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | A total of sixty one endophytic fungal isolates were screened from different parts of Catharanthus roseus plant. Plant root and Martin medium achieved the highest endophytic fungal counts. A. tubingensis, A. fumigatus and F. oxysporum were the most frequent endophytic species. The most significant total alkaloids were produced by A. fumigatus and A. tubingensis, while the least significant one was produced by Botrytis cinerea. Antimicrobial assay of the endophytic fungal extracts indicated that both A. tubingensis and F. oxysporum exhibited potent antimicrobial activities, whenever A. fumigatus exerted the least activity. In vitro cytotoxicity assay of the endophytic fungal extracts was done against human cell lines of breast cancer (MCF-7) and liver cancer (HEPG-2) using SRB assay method. A. tubingensis culture filtrate extract showed potential cytotoxic effect on MCF-7 cell line with IC50 value of 42.1 og/ml and on HEPG-2 cell line with IC50 of 48.2. The least cytotoxic effect was exhibited by F. solani. Molecular identification was done for A. tubingensis which was the most potential antimicrobial and in vitro cytotoxicity compared to other tested fungal species. In vivo cytotoxicity assay of A. tubingensis, recorded the highest in vitro cytotoxicity, was carried out. A. tubingensis extract at100 mg/kg, showed potential cytotoxic effect on EAC bearing mice groups than 50 mg/kg. The histopathological study showed that fungal extract treated group, possessed extensive apoptotic cells. Gas Chromatography Mass Spectroscopy (GC-MS) was used for analysis of alkaloids in mycelial and filtrate extracts of A.tubingiensis, F.oxysporum and F.solani where eleven alkaliods compounds were detected |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Alkaloids |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Catharanthus roseus |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Endophytic Fungi |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Azza Hassan Morsi , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Eman Abdullah Mohamed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tahany Mohamed A. Abdelrahman , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.18.M.Sc.2018.He.E | 01010110076082000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.18.M.Sc.2018.He.E | 01020110076082000 | 22.09.2023 | CD - Rom | 76082.CD |