MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02952cam a2200313 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
181010s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.08.M.Sc.2018.Ma.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mai Ahmed Tawfik |
| 245 12 - TITLE STATEMENT |
|---|
| Title |
A Pharmaceutical study on certain controlled release oral formulations of a phosphodiestrase-5 inhibitor / |
| Statement of responsibility, etc. |
Mai Ahmed Tawfik ; Supervised Magdy Ibrahim Mohamed , Mina Ibrahim Tadros |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دراسة صيدلية على بعض الصياغات الفموية منضبطة الانطلاق لعقار مثبط لانزيم فوسفودايستريز 5 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Mai Ahmed Tawfik , |
| Date of publication, distribution, etc. |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
324 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Sexual dysfunction refers to a problem during any phase of the sexual response cycle that prevents the man or couple from experiencing satisfaction from the activity. Types of sexual dysfunction include disorders involving sexual desire or libido, erection and ejaculation. Erectile dysfunction, also known as impotence, is a type of sexual dysfunction characterized by the inability to develop or maintain an erection of the penis during sexual activity. Erectile dysfunction is typically due to a combination of organic and psychololgical factors. Organic factors include cardiovascular diseases, diabetes, neurological problems, hormonal insufficiencies (hypogonadism) and drug side effects. Psychological factors include performance anxiety, stress and mental disorders. Vardenafil hydrochloride (VAR) is an erectile dysfunction treating drug. It acts through the inhibition of cGMP-specific PDE-5, the most active PDE involved in the termination of cGMP signaling in the penile corpus cavernosum and the erectile tissue in the penis. This, in turn, potentiates endogenous increases in cGMP levels in the corpus cavernosum and the vessels supplying it, thus increasing dilatation of the corporeal sinusoids allowing more blood flow, which induces an erection. VAR suffers from some limitations; including, (i) short elimination half -life (4-5 h), (ii) poor intestinal absorption due to the action of several drug efflux transporters like P-glycoprotein expressed in the luminal side of intestine, (iii) limited aqueous solubility (0.11 mg/mL), as well as (iv) the extensive first-pass metabolism (mediated by CYP3A isozymes) resulting in low absolute bioavailability (15%) |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Phosphodiestrase-5 inhibitor |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Sexual dysfunction |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Vardenafil hydrochloride (VAR) |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Magdy Ibrahim Mohamed , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mina Ibrahim Tadros , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
