MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02808cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
181020s2017 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.07.Ph.D.2017.Im.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Iman Sami Aboubakr Elbayoumi |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Role of natural killer and activating receptors in rheumatoid arthritis / |
| Statement of responsibility, etc. |
Iman Sami AbouBakr Elbayoumi ; Supervised Shereen Mahmoud Shawky , Mariam Onsy Farag , Hala Ahmed Raafat |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دور المستقبلات الناشطة للخلايا الطبيعية القاتلة فى مرض روماتويد المفاصل |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Iman Sami Aboubakr Elbayoumi , |
| Date of publication, distribution, etc. |
2017 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
211, 26 P. : |
| Other physical details |
charts ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Introduction: Rheumatoid arthritis (RA) is a common chronic autoimmune disease (AID). The impaired activity of the effector lymphocytes: NK cells, T cells and NKT cells, has been detected in RA. Dysregulation of Natural Killer Receptors (NKRs) in patients with RA has been shown. In Egypt, the prevalence rate of HCV (genotype 4) reaches 20%. Because of the high prevalence of the two diseases, HCV-infected patients having arthritis, and classical RA with concomitant HCV, pose a diagnostic problem for rheumatologists. Objectives: In the present work we aimed to study the characterization: The count and the NKRs (CD16 and CD244) expression on the three types of effector lymphocytes, in RA patients and in RA patients with concomitant HCV to investigate their role in the pathogenesis of RA and to detect the difference between their character in RA patients and RA with HCV. Patients and methods: The count of NK, T and NKT cells, the expression of CD16 and CD244 on the 3 effector lymphocytes, were evaluated in 20 RA patients, 21 RA patients with HCV and 17 healthy control with flow cytometry. Cytokines influencing NK cell as TNF-Ü and IL-6 were measured by IRMA and by ELISA respectively. Results: Our main finding was the significantly reduced MFI of CD16 and CD244 on NK, T and NKT cells, in the RA patients with HCV and RA without HCV, compared to the control and a significant increase of percentage and absolute NKT cell count, in the RA patients with HCV and RA without HCV compared to the healthy control |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
CD16 |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Hepatitis C virus |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Rheumatoid arthritis |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Hala Ahmed Raafat , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mariam Onsy Farag , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Shereen Mahmoud Shawky , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samia |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
