Effect of thyroid hormones on a male rat model of renal ischemia reperfusion injury : (Record no. 68124)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03304cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032104.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 181022s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.30.M.Sc.2018.Re.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Reem Esam Abdelrahman Ghoweba |
| 245 10 - TITLE STATEMENT | |
| Title | Effect of thyroid hormones on a male rat model of renal ischemia reperfusion injury : |
| Remainder of title | Possible role of Poly(ADP-ribose) polymerase / |
| Statement of responsibility, etc. | Reem Esam Abdelrahman Ghoweba ; Supervised Akef Abdelhalim Khowailed , Laila Ahmed Rashed , Hend Ashour Ahmed Hassan |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تأثير هرمون الغدة الدرقية على القصور الاروائى و إعادة ارتواء الكلى فى ذكور الفئران : |
| Remainder of title | الدور المحتمل لانزيم بولى ريبوزبوليميريز |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Reem Esam Abdelrahman Ghoweba , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 180 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Physiology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction : Renal ischemia reperfusion (IRI) injury is one of the major causes of acute kidney injury (AKI). The relationship between kidney and thyroid function has been well known for many years. Poly(ADP-ribose) polymerase (PARP) is a nuclear protein that is important for DNA repair, but its excessive activation is important in necrotic cell death. It remains unknown whether there is a relationship between thyroid hormones and PARP-1 expression during renal IRI or not.Aim: To elucidate the role of the thyroid hormones preconditioning in renal ischemia reperfusion injury and its possible role in the regulation of the PARP-1 activity. We also considered the pathological conditions of thyroid hormones (hypo and hyperthyroidism) and their effects on renal ischemia reperfusion injury.Methods: A total of 50 male albino rats 180-200 gm were designated randomly into the following five groups (10 rats in each group);group Ї: sham operated for renal IRI (Sham), group ЇЇ: (Euthyroid+IRI), group ЇЇЇ: (Hyperthyroidism+IRI), group ЇV: (preconditioned+IRI) and group V: (Hypothyroidism+IRI).Prior to surgery the thyroid state was confirmed by analysis of thyroid profile (T3, T4 and TSH) for all animals.At the end of the experimental period, systolic& diastolic blood pressure was measured, 24h urine was collected and body weight was measured for GFR determination. Blood samples were collected for assessment of angiotensin II, BUN and plasma creatinine. Tissue samples from the kidney for histopathological examination and for measuring the following parameters: malondialdehyde (MDA), superoxide dismutase (SOD), neutrophil gelatinase-associated lipocalin (NGAL), activating protein 1 (AP-1), Caspase 3, ATP, poly(ADP-ribose) polymerase (PARP-1) activity in the kidney |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | IRI |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Kidney |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Thyroid hormones |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Akef Abdelhalim Khowailed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hend Ashour Ahmed Hassan , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Laila Ahmed Rashed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.30.M.Sc.2018.Re.E | 01010110076210000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.30.M.Sc.2018.Re.E | 01020110076210000 | 22.09.2023 | CD - Rom | 76210.CD |