The potential effect of doxycycline versus pregabalin on neuropathic pain in streptozotocin induced diabetes in rats / (Record no. 68185)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03245cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032106.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 181027s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.29.M.Sc.2018.Di.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Dina Anwar Ibrahim |
| 245 14 - TITLE STATEMENT | |
| Title | The potential effect of doxycycline versus pregabalin on neuropathic pain in streptozotocin induced diabetes in rats / |
| Statement of responsibility, etc. | Dina Anwar Ibrahim ; Supervised Eman Abdelmonem Abdelrasheed , Olfat Gamil Shaker , Magdy Ishak Attallah |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التاثير المحتمل لدواء الدوكسيسيكلين مقارنة بالبريجابالين على الالم الاختلالى العصبى الناتج من مرض السكر المحدث بالستربتوزوتوسين فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Dina Anwar Ibrahim , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 156 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pharmacology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background and aim: Diabetic neuropathy (DN) is a major complication of diabetes frequently accompanied with pain sensation. Pathogenesis of painful diabetic neuropathy is multifactorial. Many factors including metabolic, vascular and immunological components are involved in the pathogenesis. Doxycycline, a second generation tetracycline, is well known to have anti-inflammatory effect beyond its antimicrobial activity. Objectives: The present study was designed to investigate the potential role of Doxycycline in treatment of painful diabetic neuropathy in comparison with pregabalin materials and methods: Male wistar strain rats weighing (150-200g) were used. Diabetic neuropathy was induced in rat by I.P. injection of single dose of STZ 50mg/kg. Two doses of Doxycycline 50 and 100 mg/kg were examined. Pregabalin was used as a standard drug for comparison. Tests for mechanical and thermal allodynia and hyperalgesia were used to assess the antinociceptive effect of the tested drugs. The serum level of glucose and HBA1C were measured and the level of IL-1Ý and TNF-Ü in spinal cord homogenate were measured. Moreever, histopathological examination of sciatic nerve was done. Results: The results of the present study showed that doxycycline administration in the two specified doses showed significant improvement of measurement of all behavioral tests including hot plate, analgesy-meter tests and acetone test which was comparable with that occurred with administration of Pregabalin. Both doxycycline tested doses and pregabalin administrated to hyperglycemic rats produced significant reduction in levels of IL1 beta and TNF alpha in spinal cord homogenate and significant reduction of blood glucose level in diabetic rats |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Doxycycline |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Neuropathic pain |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pregabalin |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Eman Abdelmonem Abdelrasheed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Magdy Ishak Attallah , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Olfat Gamil Shaker , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.29.M.Sc.2018.Di.P | 01010110076261000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.29.M.Sc.2018.Di.P | 01020110076261000 | 22.09.2023 | CD - Rom | 76261.CD |