MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03218cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
181030s2018 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.33.Ph.D.2018.Ah.V |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ahmed Abdelmonem Mohamed Cordie Abdelhamid |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Virologic response following combined daclatasvir and sofosbuvir administration in patients with HCV and HIV co-infection / |
| Statement of responsibility, etc. |
Ahmed Abdelmonem Mohamed Cordie Abdelhamid ; Supervised Gamal Eldin Esmat Mohamed Gamil , Aisha Mahmoud Elsharkawy , Safa Sayed Mashaal |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
الأستجابة الفيروسيه بعد أعطاء عقار الدكلاتسفير بمصاحبة عقار السوفوسبوفير في المرضي المصابين بالعدوي المشتركه بفيروس نقص المناعه المكتسبة و الألتهاب الكبدي الوبائي المزمن الفيروسي سي |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Ahmed Abdelmonem Mohamed Cordie Abdelhamid , |
| Date of publication, distribution, etc. |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
150 P. : |
| Other physical details |
charts ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Background: Hepatitis C virus {uFD3E}HCV{uFD3F} co{u2010}infection among people living with human immunodeficiency virus {uFD3E}PLHIV{uFD3F} is a growing worldwide health burden. Genotype 4 accounts for more than 90% of existing HCV in Egypt. Although treatment of hepatitis C genotype 4 has become very effective in Egypt, there is no data about safety and efficacy of used direct acting antiviral agents (DAAs) in HCV co-infected PLHIV. Aim of work: To demonstrate SVR rate, side effects profile, immunologic response and HIV suppression state after using the combination of daclatasvir and sofosbuvir for treating 50 HIV/HCV co-infected patients. Patients and methods: In this cohort study, 50 eligible patients with confirmed genotype 4 HCV/HIV co-infection were enrolled between November 2015 and June 2017 to recieve HCV treatment (12 weeks of daclatasvir 60 mg daily with dose adjustment for concomitant antiretroviral medications if any, plus 400 mg of sofosbuvir daily). Serial measurements of safety parameters, virologic and host immune correlates, and adherence were performed during treatment and 12 weeeks after treatment. Results: Overall, 47 patients achieved sustained virological response at week 4 post treatment (SVR 4) (94%) and 44 patients at week 12 (SVR 12) (88%). In the per protocol population, the SVR 4 and SVR 12 were (47/48, 97.9%) and (44/47, 93.6%) respectively. The most common adverse events were fatigue (32%), headache (20%). No patient discontinued treatment because of adverse events. No serious adverse events or mortality were reported. No alteration of HIV suppression was determined |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
DAAs |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
HCV/HIV co-infection |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
SVR |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Aisha Mahmoud Elsharkawy , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Gamal Eldin Esmat Mohamed Gamil , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Safa Sayed Mashaal , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
