MARC details
| 000 -LEADER |
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| fixed length control field |
03518cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
181103s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
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| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| Classification number |
Cai01.11.16.M.Sc.2018.Ra.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Rana Maged Yakout |
| 245 14 - TITLE STATEMENT |
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| Title |
The possible protective effect of CoQ10 enzyme on Methotrexate-induced cerebellar toxicity in adult male albino rats : |
| Remainder of title |
A histological and immunohistochemical study / |
| Statement of responsibility, etc. |
Rana Maged Yakout ; Supervised Soad Jimmy Tadros , Mary Attia Morcos , Abeer Ibraheem Abdallah |
| 246 15 - VARYING FORM OF TITLE |
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| Title proper/short title |
على درجة السمية في المخيخ المستحدثة بالميثوتريكسيت في ذكور الجرذان البيضاء البالغين CoQ10 التأثير الوقائي المحتمل لإنزيم : |
| Remainder of title |
دراسة هستولو{uئآ٧ؤ}ية وهستوكيميائية مناعية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Rana Maged Yakout , |
| Date of publication, distribution, etc. |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
103 P. : |
| Other physical details |
charts , facimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Histology |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Background : Methotrexate (MTX), as an antineoplastic agent, can cause serious side effects including neurotoxicity. The most common mechanism of MTX induced damage is oxidative stress. CoenzymeQ10 (CoQ10) is a potent antioxidant that protects cells from damage and plays an important role in metabolism. Aim: This study was designed to evaluate the possible therapeutic effect of CoQ10 on the cerebellar histological changes induced by MTX in the brain of adult male albino rats.Materials and methods: Fourty eight adult male albino rats were divided into three groups namely, Control group (I), MTX group (II),which received single intraperitoneal dose of MTX (20mg/kg) and MTX+CoQ10 (III) which received MTX (as group II) and CoQ10 in a dose of 200mg daily orally by gastric tube.They were subdivided into subgroups a and b, then sacrificed 3 and 5 weeks from the start of the experiment, respectively. Cerebellar specimens were processed for histological (H&E and Toluidine blue stains) and immunohistochemical [anti-Glial Fibrillary Acidic Protein (GFAP)] antibodies studies. Mean area percent of GFAP positive reaction and mean number of Purkinje cells were detected, then the data were statistically analyzed. Results: Methotrexate treatment (group II) caused degenerative changes in Purkinje cells as many cells appeared shrunken with dark pyknotic nuclei. Vaculations in the molecular layer (ML) and splitting of myelinated nerve fibers were detected in the white matter. The Mean area percent of GFAP immunoreaction showed significant increase as compared to control group. CoQ10 treatment ( group III) resulted in amelioration of cell degeneration which was more evident in subgroup IIIb. Moreover, there was significant decrease in GFAP immunoreactivity. Conclusion: CoQ10 enzyme oral administration in rats following MTX-induced cerebellar toxicity, could ameliorate the neurodegenerative changes occurring in the cerebellum especially when administration continue for long period |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Cerebellar toxicity |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
CoQ10 enzyme |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Methotrexate |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Abeer Ibraheem Abdallah , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Mary Attia Morcos , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Soad Jimmy Tadros , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
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| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
