Study of the effect of filtered packed RBCs transfusion on the innate immunty of the critically-ill children represented by interleukin-6 / (Record no. 68664)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03388cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032120.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 181124s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.28.M.Sc.2018.As.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Aseel Ehab Mohamed Mahmoud |
| 245 10 - TITLE STATEMENT | |
| Title | Study of the effect of filtered packed RBCs transfusion on the innate immunty of the critically-ill children represented by interleukin-6 / |
| Statement of responsibility, etc. | Aseel Ehab Mohamed Mahmoud ; Supervised Seham Awad Elsherbini , Yomna Mousa Shaalan , Ahmed Mohamed Abdelhafez |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة تأثير نقل كرات الدم الحمراء المفلترة على مناعة أطفال الرعاية المركزة عن طريق قياس مادة انترلوكن- ٦ بالدم |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Aseel Ehab Mohamed Mahmoud , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 146 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: Anemia is highly prevalent in the developing world and often it is aggravating in critically-ill children, which necessitates blood transfusion. Complications depend on different factors mostly filtration and storage of blood. The main cause of these complications can be explained by its effect on the innate immunity which can be represented by interleukin-6. Usage of fresh blood has a more beneficial effect than stored blood. Objectives:The aim of the study is to evaluate the role of interleukin-6 in determining the extent of innate immunity affection after packed RBCs transfusion in critically-ill children. Subjects and methods: This is a cross sectional study conducted on 30 patients before and after blood transfusion to determine interleukin-6 level in both occasions with the use of fresh and stored blood to detect the degree of immune affection with the use of each individually and monitoring the patients on day 2 and day 7 after transfusion for their clinical manifestations. Results:Packed RBCs transfusion causes immunosuppression which appeared here in the reduction of interleukin-6 although it was statistically non-significant (p{u02C3}0.05).Neurological system showed more dysfunction with the use of stored blood (p{u02C2}0.001), longer hospital stay was found in the stored blood group (p=0.041), more sepsis (p=0.001), more acute lung injury (p=0.028), acute respiratory distress syndrome (p=0.008), and death (p=0.001) all occurred with the stored blood group. Those who needed longer mechanical ventilation had a more reduction in IL6 r=0.442 (p=0.045) and further transfusions r=0.491 (p=0.006)confirming the suppression that had occurred in their innate immunity.Non-significant statistical difference had occurred with increasing the number of transfusions as regards the all measured parameters (p{u02C3}0.05) may be due to small sized samples |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Immunosuppression |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Stored blood |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Transfusion |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Mohamed Abdelhafez , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Seham Awad Elsherbini , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yomna Mousa Shaalan , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.28.M.Sc.2018.As.S | 01010110076394000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.28.M.Sc.2018.As.S | 01020110076394000 | 22.09.2023 | CD - Rom | 76394.CD |