Expression of micro-RNA 128 and Let-7b in pediatric ALL / (Record no. 69243)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02726cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032138.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 181224s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.19.03.Ph.D.2018.Sa.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Salwa Aly Elsaid Senoun |
| 245 10 - TITLE STATEMENT | |
| Title | Expression of micro-RNA 128 and Let-7b in pediatric ALL / |
| Statement of responsibility, etc. | Salwa Aly Elsaid Senoun ; Supervised Nahed Abdelwahab Mohamed , Emad Nabil Ebed , Maha Abdelhamid Eltaweel |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | بي7في سرطان الدم الليمفي الحاد عند الأطفال- Let-128- RNAظهور ميكرو |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Salwa Aly Elsaid Senoun , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 150 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Recently, growing evidence has implicated specific miRNAs in the pathogenesis of leukemia and circulating miRNAs could serve as noninvasive biomarkers for detection of leukemia. In tumor cells, miR-128 expression is dysregulated through a variety of genetic and epigenetic events. Deregulation of Let-7 in various cancers suggest that Let-7 may have different functions in different diseases or in different cell contexts. Aim of the work: to evaluate the expression of both miRNAs, miR-128 and Let-7b, in a newly diagnosed bone marrow samples from children with Acute Lymphoblastic Leukemia (ALL) and to correlate their expression levels with clinical and Laboratory data. Material and methods: Detection of micro-RNA 128 and Let-7b using RTPCR in 70 newly diagnosed ALL pediatric patients and 7 age and sex comparable healthy control. Results: we found that miR128 was significantly upregulated in pediatric ALL bone marrow (BM) samples compared to control BM samples (P<0.001).however, no statistical significant difference in Let -7b expression between pediatric ALL group compared to control group (P=0.126). Conclusion: miR-128 was found to be expressed at a significantly higher level in ALL than in normal subjects, which may help to provide new insights into the diagnosis of childhood ALL and that the role of Let -7b has to be verified by further large scale sample and further studies |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Let-7b |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Micro-RNA 128 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pediatric ALL |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Emad Nabil Ebed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Maha Abdelhamid Eltaweel , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nahed Abdelwahab Mohamed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.19.03.Ph.D.2018.Sa.E | 01010110076590000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.19.03.Ph.D.2018.Sa.E | 01020110076590000 | 22.09.2023 | CD - Rom | 76590.CD |